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Botensilimab

(Synonyms: AGEN 1181)
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Botensilimab (AGEN 1181), a human anti-cytotoxic T-lymphocyte antigen 4 (CTLA-4) monoclonal antibody, is an innate and adaptive immune activator. Botensilimab can be used for the research of cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

  • Pureté: 99.00%
  • CAS No.: 2408310-37-0
  • Masse moléculaire:144.54 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Botensilimab
  • Experimental Validation Results for Botensilimab
  • Experimental Validation Results for Botensilimab
  • Experimental Validation Results for Botensilimab
  • Botensilimab Chemical Structure
    Botensilimab Chemical Structure
CAS No.: 2408310-37-0
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Botensilimab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Immobilized Human CTLA-4 Protein (His Tag) can bind Botensilimab. The EC50 for this effect is 2.04 ng/mL.

  • 1/16

    Loaded Botensilimab on AHC2 biosensor, can bind CTLA-4 Protein, Human (HEK293, His, HY-P70684) with an affinity constant of 8.815E-10 M as determined in BLI assay.

  • 1/16

    Flow Cytometry analysis of Raji cells labelling CTLA4 (red) with Botensilimab (HY-P99484). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Botensilimab Chemical Structure
    1/16
  • Botensilimab
  • Immobilized Human CTLA-4 Protein (His Tag) can bind Botensilimab. The EC50 for this effect is 2.04 ng/mL.
  • Loaded Botensilimab on AHC2 biosensor, can bind CTLA-4 Protein, Human (HEK293, His, HY-P70684) with an affinity constant of 8.815E-10 M as determined in BLI assay.
  • Flow Cytometry analysis of Raji cells labelling CTLA4 (red) with Botensilimab (HY-P99484). Cells were fixed with 4% paraformaldehyde and permeabilised with 90% methanol. Then cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG1 Isotype Control (HY-P99001, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).