country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-161938

Copy Link Print Information

BRD8518

BRD8518 is a PCSK9 inhibitor (EC₅₀=0.23 μM). BRD8518 lowers blood lipids by upregulating LDLR expression and stimulating LDL uptake. BRD8518 can be used in the study of cardiovascular diseases.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1565828-01-4
Formule: C₃₃H₃₂F₃N₃O₅
Masse moléculaire:607.62

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

BRD8518 Chemical Structure

CAS No.: 1565828-01-4

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	EC₅₀	0.23 μM Compound: 1; BRD8518	Induction of TRIB1 expression in human HepG2 cells measured after overnight incubation by qRT-PCR analysis Induction of TRIB1 expression in human HepG2 cells measured after overnight incubation by qRT-PCR analysis	[PMID: 30542533]
HepG2	EC₅₀	0.24 μM Compound: 1; BRD8518	Down regulation of PCSK9 gene expression in human HepG2 cells measured after 24 hrs by qRT-PCR analysis Down regulation of PCSK9 gene expression in human HepG2 cells measured after 24 hrs by qRT-PCR analysis	[PMID: 30542533]
HepG2	EC₅₀	0.36 μM Compound: 77	Inhibition of PCSK9 mRNA expression in human HepG2 cells after 24 hrs by qRT-PCR analysis Inhibition of PCSK9 mRNA expression in human HepG2 cells after 24 hrs by qRT-PCR analysis	[PMID: 30448414]
HepG2	EC₅₀	0.43 μM Compound: 1; BRD8518	Up regulation of TRIB1 gene expression in human HepG2 cells measured after 6 hrs by qRT-PCR analysis Up regulation of TRIB1 gene expression in human HepG2 cells measured after 6 hrs by qRT-PCR analysis	[PMID: 30542533]
HepG2	EC₅₀	0.49 μM Compound: 1; BRD8518	Up regulation of LDLR gene expression in human HepG2 cells measured after 6 hrs by qRT-PCR analysis Up regulation of LDLR gene expression in human HepG2 cells measured after 6 hrs by qRT-PCR analysis	[PMID: 30542533]

Chemical Information

CAS No. 1565828-01-4
Masse moléculaire 607.62
Formule C₃₃H₃₂F₃N₃O₅
SMILES

O=C(NC1=CC=C2C(C(N(C)[C@H]3CC[C@@H](CC(NC4CC(C=CC=C5)=C5C4)=O)O[C@H]3CO2)=O)=C1)C6=CC=C(C(F)(F)F)C=C6
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Xuhui Bao, et al. "Targeting proprotein convertase subtilisin/kexin type 9 (PCSK9): from bench to bedside." Signal Transduction and Targeted Therapy 9.1 (2024): 13. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis