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Cat. No.: HY-114721

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BTA-9881

Name: BTA-9881
Brand: MedChemExpress
SKU: HY-114721
Price: 192.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: MEDI-564)

BTA-9881 (MEDI-564) is a RSV inhibitor, with an EC₅₀: 48 nM, 59 nM and 160 nM for RSV A2, RSV Long, and RSV B1. BTA-9881 has favorable pharmacokinetics property.

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CAS No.: 1646857-24-0
Formule: C₂₁H₁₅ClN₄O₂
Masse moléculaire:390.82

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

BTA-9881 Chemical Structure

CAS No.: 1646857-24-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- Essai clinique
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

BTA-9881 (MEDI-564) is a RSV inhibitor, with an EC₅₀: 48 nM, 59 nM and 160 nM for RSV A2, RSV Long, and RSV B1. BTA-9881 has favorable pharmacokinetics property^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEp-2	EC₅₀	0.048 μM Compound: 33a	Antiviral activity against respiratory syncytial virus A2 infected in human Hep2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay Antiviral activity against respiratory syncytial virus A2 infected in human Hep2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 25595685]
HEp-2	EC₅₀	0.059 μM Compound: 33a	Antiviral activity against respiratory syncytial virus Long infected in human Hep2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay Antiviral activity against respiratory syncytial virus Long infected in human Hep2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 25595685]
HEp-2	EC₅₀	0.16 μM Compound: 33a	Antiviral activity against respiratory syncytial virus B1 infected in human Hep2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay Antiviral activity against respiratory syncytial virus B1 infected in human Hep2 cells assessed as reduction in virus-induced cytopathic effect after 5 days by MTT assay	[PMID: 25595685]

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 1646857-24-0
Masse moléculaire 390.82
Formule C₂₁H₁₅ClN₄O₂
SMILES

O=C1N2[C@@](C3=CC=C(C=C3)Cl)(N(CC2)C(C4=CC=CN=C4)=O)C5=C1C=CN=C5
Synonyms

MEDI-564
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Bond S, et al. 1,2,3,9b-Tetrahydro-5H-imidazo[2,1-a]isoindol-5-ones as a new class of respiratory syncytial virus (RSV) fusion inhibitors. Part 2: identification of BTA9881 as a preclinical candidate. Bioorg Med Chem Lett. 2015 Feb 15;25(4):976-81. [Content Brief]

Calculators

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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