C201-0243
Based on 1 Customer Validation
C201-0243 is an FcRn antagonist with an IC50 of 3.439 nM. C201-0243 competitively blocks the binding of IgG to FcRn.
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- Pureté : 99.65%
- CAS No.: 931360-60-0
- Formule: C18H16FN3O3
- Masse moléculaire:341.34
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Stockage:
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
FcRn 3.439 nM (IC50) |
In Vitro
C201-0243 (0.0001-10000 nM) exhibits FcRn antagonistic activity in a competitive ELISA, and its dose-response curve is consistent with the trend of the positive control[1].
C201-0243 (1666-1.16 × 10-4 nM; 1.5 h) inhibits FcRn binding to immobilized IgG in a cell-free competitive ELISA with an IC50 of 3.439 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 931360-60-0
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Appearance Solid
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Masse moléculaire 341.34
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Formule C18H16FN3O3
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Color Light yellow to yellow
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SMILES
O=C(C1=CC2=C(CO)C=NC(C)=C2OC1=N)NC3=CC(F)=CC=C3C
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
Solvant et solubilité
In Vitro:
DMSO : 4 mg/mL (11.72 mM; Need warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureté et documentation
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Fiche technique (274 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9296 mL | 14.6482 mL | 29.2963 mL | 73.2408 mL |
| 5 mM | 0.5859 mL | 2.9296 mL | 5.8593 mL | 14.6482 mL | |
| 10 mM | 0.2930 mL | 1.4648 mL | 2.9296 mL | 7.3241 mL |
C201-0243 Related Classifications
HY-179609 Related Classifications
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