Canine Factor IX
Based on 1 Customer Validation
Canine Factor IX is a functional coagulation factor. Canine Factor IX shortens whole blood clotting time and activated partial thromboplastin time, and restores coagulation function. After intramuscular administration via rAAV vector in hemophilia B dogs, Canine Factor IX maintains a sustained circulating level for at least 1 year, partially corrects the hemophilia B phenotype in a dose-dependent manner, and its plasma expression persists for more than 17 months. Canine Factor IX is applicable to relevant research on hemophilia B.
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- CAS No.: 9001-28-9
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Canine Factor IX (104-105 vector particles/cell; 36 h post-transduction) was secreted in biologically active form following transduction of HEK-293 cells with AAV-CMV-cF.IX vector, measurable via ELISA of cell supernatants[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK-293 cells
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Concentration:104, 105 vector particles/cell
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Incubation Time:36 h post-transduction
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Result:Resulted in detectable secretion of biologically active canine Factor IX into cell supernatants.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Outbred dogs (male and female; 2, 4, 8 months old; 5.7-20 kg; spontaneous severe hemophilia B with undetectable endogenous F.IX)[2]
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Dosage:1.3 × 1011; 1.1 × 1012; 3.4 × 1012; 3 × 1012; 8.5 × 1012 vector particles/kg
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Administration:i.m.; single dose
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Result:Was stably expressed in plasma in a dose-dependent manner, reaching up to 69 ng/ml, WBCT and APTT were persistently shortened, immune responses against cFIX were absent or transient, and no local or systemic toxicity was observed.
Chemical Information
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CAS No. 9001-28-9
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Appearance Solid
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Color White to off-white
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SMILES
[Canine Factor IX]
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Livraison
Shipping with dry ice.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (268 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Chao H, et al. Persistent expression of canine factor IX in hemophilia B canines. Gene Ther. 1999;6(10):1695-1704. [Content Brief]
[2]. Herzog RW, et al. Long-term correction of canine hemophilia B by gene transfer of blood coagulation factor IX mediated by adeno-associated viral vector. Nat Med. 1999;5(1):56-63. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Canine Factor IX Related Classifications
HY-E70541B Related Classifications
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