CB2-H
CB2-H is a dual-channel fluorescent probe for the simultaneous detection of HOCl and ONOO-. CB2-H enables the concurrent detection of HOCl and ONOO- at two independent channels without spectral cross-interference and can be applied for dual-channel fluorescence imaging of endogenously produced HOCl and ONOO- in living cells and zebrafish under different stimulants.
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- Formule: C29H23Br2N3O5
- Masse moléculaire:653.32
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
ONOO- can selectively oxidize the hydrazide group of CB2-H to afford the parent dye CB2 (Absmax/Emmax = 631/669 nm). In the case of HOCl, it undergoes an electrophilic attack on the benzopyran moiety of CB2-H to give a chlorinated product CB2-H-Cl, which inhibits the PET process within the probe and thus affords a turn-on fluorescence response at the coumarin channel (Absmax/Emmax = 407/468 nm)[1].
CB2-H (5 μM; 30 min) is capable of concurrently monitoring endogenously produced HOCl and ONOO- in living cells and zebrafish under different stimulants[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 653.32
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Formule C29H23Br2N3O5
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SMILES
CCN(C1=CC=C2C(OC(C3=CC4=C(C(Br)=C(C(Br)=C4)O)OC3=O)=CC25C6=C(C(N5N)=O)C=CC=C6)=C1)CC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CB2-H Related Classifications
HY-152103 Related Classifications
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