Cgs 27830
Cgs 27830 is an endothelin receptor antagonist with 20-fold higher selectivity for ET-A receptors over ET-B receptors. Cgs 27830 blocks activity of ET-A and ET-B receptors. Cgs 27830 does not alter basal vascular tone in the ovine fetal pulmonary circulation. Cgs 27830 prevents big-endothelin-1-induced pulmonary vasoconstriction in late gestation fetal lambs.
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- CAS No.: 155485-56-6
- Formule: C32H30N4O11
- Masse moléculaire:646.60
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Activité biologique
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Activité biologique
Description
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Columbia-Rambouillet (mixed breed, late gestation 131 days)[1]
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Dosage:100 mcg/min
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Administration:intrapulmonary infusion; 10 min
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Result:Did not alter baseline left pulmonary artery flow, mean pulmonary artery pressure, mean aortic pressure, left atrial pressure, pulmonary vascular resistance, heart rate, or blood gas parameters.
Blocked the big-ET-1-induced increase in pulmonary vascular resistance.
Blocked the big-ET-1-induced rise in mean pulmonary artery pressure.
Prevented changes in left pulmonary artery flow.
Chemical Information
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CAS No. 155485-56-6
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Masse moléculaire 646.60
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Formule C32H30N4O11
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SMILES
O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=CC([N+]([O-])=O)=CC=C2)OC(C3=C(C)NC(C)=C(C(OC)=O)[C@H]3C4=CC([N+]([O-])=O)=CC=C4)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cgs 27830 Related Classifications
HY-182561 Related Classifications
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