Clathrin-IN-5
Clathrin-IN-5 (Compound 9) is a Clathrin N-terminal domain-Amphiphysin protein-protein interaction inhibitor with an IC50 of 2.77 μM. Clathrin-IN-5 inhibits the protein-protein interaction between the clathrin N-terminal domain and amphiphysin. Clathrin-IN-5 inhibits clathrin-mediated endocytosis with an IC50 of 4.6 μM. Clathrin-IN-5 inhibits the GTPase activity of Dynamin I with an IC50 of 29.7 μM.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 339025-18-2
- Formule: C16H10ClNO3
- Masse moléculaire:299.71
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
Dynamin I 29.7 μM (IC50) |
In Vitro
Clathrin-IN-5 potently inhibits the Clathrin N-terminal domain-amphiphysin protein-protein interaction with an IC50 of 2.77 ± 0.9 μM in an ELISA-based binding assay[1].
Clathrin-IN-5 inhibits clathrin-mediated endocytosis in U2OS osteosarcoma cells with an IC50 of 4.6 ± 0.5 μM[1].
Clathrin-IN-5 inhibits full-length human dynamin I GTPase activity with an IC50 of 29.7 ± 3.3 μM in an in vitro colorimetric assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 339025-18-2
-
Masse moléculaire 299.71
-
Formule C16H10ClNO3
-
SMILES
OC1=CC(NC(C(C2=C3C=CC=C2)=O)=C(Cl)C3=O)=CC=C1
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Hot Topics
-
All
-
Topics
-
Most Recent
-
Oldest
-
Topics Protein-Protein Interaction: Therapeutic Target-Beyond Cancer
Protein-protein interactions (PPIs) constitute the molecular framework that organizes signaling networks, gene regulation, metabolism, immunity, and cellular homeostasis.
2026-06-18
-
Topics A Review of the Mechanisms and Applications of Protein-Protein Interactions (PPIs)
Protein-protein interactions (PPIs) are physical or functional connections formed by two or more proteins through specific interfaces, and they underlie signal transduction, transcriptional regulation, protein degradation, cell-cycle control, DNA repair, immune recognition, and cell death.
2026-06-18
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Clathrin-IN-5 Related Classifications
HY-181933 Related Classifications
Powered by Bioz