Clonixeril
Based on 1 Customer Validation
Clonixeril (NSC 335504) is a non-nucleotide hSTING modulator. Clonixeril has weak agonist activity at micromolar concentrations and results in antagonism of the hSTINGWT pathway at low femtomolar (10-15 M) and in some cases even attomolar (10-18 M) concentrations. Clonixeril reduces hSTING oligomerization at a concentration of 1 aM-1 pM.
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- Pureté: 99.63%
- CAS No.: 21829-22-1
- Formule: C16H17ClN2O4
- Masse moléculaire:336.77
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | IC50 |
>2.0 × 105M
Compound: COVC-3898875898
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Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
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10.6019/CHEMBL4651402 |
Chemical Information
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CAS No. 21829-22-1
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Appearance Solid
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Masse moléculaire 336.77
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Formule C16H17ClN2O4
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Color White to off-white
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SMILES
O=C(C1=CC=CN=C1NC2=C(C)C(Cl)=CC=C2)OCC(CO)O
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Synonyms
NSC 335504
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 100 mg/mL (296.94 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (271 KB)
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SDS (254 KB)
- English - EN (254 KB)
- Français - FR (254 KB)
- Deutsch - DE (254 KB)
- Norwegian - NO (254 KB)
- Español - ES (254 KB)
- Swedish - SV (254 KB)
- Italian - IT (254 KB)
- Korean - KR (254 KB)
- Portuguese - PT (254 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9694 mL | 14.8469 mL | 29.6939 mL | 74.2346 mL |
| 5 mM | 0.5939 mL | 2.9694 mL | 5.9388 mL | 14.8469 mL | |
| 10 mM | 0.2969 mL | 1.4847 mL | 2.9694 mL | 7.4235 mL | |
| 15 mM | 0.1980 mL | 0.9898 mL | 1.9796 mL | 4.9490 mL | |
| 20 mM | 0.1485 mL | 0.7423 mL | 1.4847 mL | 3.7117 mL | |
| 25 mM | 0.1188 mL | 0.5939 mL | 1.1878 mL | 2.9694 mL | |
| 30 mM | 0.0990 mL | 0.4949 mL | 0.9898 mL | 2.4745 mL | |
| 40 mM | 0.0742 mL | 0.3712 mL | 0.7423 mL | 1.8559 mL | |
| 50 mM | 0.0594 mL | 0.2969 mL | 0.5939 mL | 1.4847 mL | |
| 60 mM | 0.0495 mL | 0.2474 mL | 0.4949 mL | 1.2372 mL | |
| 80 mM | 0.0371 mL | 0.1856 mL | 0.3712 mL | 0.9279 mL | |
| 100 mM | 0.0297 mL | 0.1485 mL | 0.2969 mL | 0.7423 mL |
Clonixeril Related Classifications
HY-171012 Related Classifications
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