CRL-42872
CRL-42872 is an orally active, highly bioavailable Gp IIb/IIIa platelet receptor inhibitor. CRL-42872 inhibits the binding of fibrinogen to the Gp IIb/IIIa receptor, thereby suppressing collagen-induced platelet aggregation. CRL-42872 is widely used in thrombosis-related studies.
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- CAS No.: 256385-24-7
- Formule: C22H27ClN6O6S
- Masse moléculaire:539.00
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
Description
In Vitro
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Dunkin-Hartley (male, ~330 g)[1]
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Dosage:10 mg/kg
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Administration:p.o.; single dose
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Result:Inhibited collagen-induced platelet aggregation by 68% at 1 hour post-administration.
Inhibited collagen-induced platelet aggregation by 64% at 2 hours post-administration.
Chemical Information
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CAS No. 256385-24-7
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Masse moléculaire 539.00
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Formule C22H27ClN6O6S
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SMILES
O=C1CN(C2=CC=C(C=C2)C(N)=N)CCN1CC(NC[C@@H](C(O)=O)NS(=O)(C3=CC=CC=C3)=O)=O.Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CRL-42872 Related Classifications
HY-119238 Related Classifications
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Keywords
- CRL-42872
- 256385-24-7
- CRL42872
- CRL 42872
- P-glycoprotein
- P-gp
- Pgp
- Multidrug resistance protein 1
- MDR1
- ATP-binding cassette sub-family B member 1
- ABCB1
- Cluster of differentiation 243
- CD243
- collagen-induced platelet aggregation
- human
- thrombosis
- guinea pig
- fibrinogen
- antithrombotic activity
- Gp IIb/IIIa platelet receptor
- platelet aggregation
- Inhibitor
- inhibitor
- inhibit