DDO-02005
DDO-02005 is a potent Kv1.5 potassium channel inhibitor with an IC50 value of 0.72 μM. DDO-02005 has good anti-atrial fibrillation (AF) effect in CaCl2-ACh AF rats model and effective anti-arrhythmic activity caused by aconitine.
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- CAS No.: 1186049-44-4
- Formule: C21H27Cl2N3O2
- Masse moléculaire:424.36
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 0.72 μM (Kv1.5 potassium channel)[1]
Pharmacokinetic Parameters of DDO-02005 in Sprague-Dawley rats[1].
| IV (1 mg/kg) | PO (1.25 mg/kg) | |
| t1/2 (h) | 3.23 ± 1.07 | 6.25 ± 2.40 |
| Cmax (μg/L) | 90.23 ± 28.83 | 1.27 ± 0.40 |
| AUC0-t (μg/L·h) | 178.42 ± 39.33 | 4.41 ± 0.69 |
| CL (L/h/kg) | 5.83 ± 1.44 | 36.51 ± 2.54 |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1186049-44-4
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Masse moléculaire 424.36
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Formule C21H27Cl2N3O2
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SMILES
COC1=CC=C(C=C1)CNC2CCN(CC3=NC4=CC=CC=C4O3)CC2.[H]Cl.[H]Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DDO-02005 Related Classifications
HY-144801A Related Classifications
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