DMG-PEG2000-Asp6

DMG-PEG2000-Asp6 is composed of three covalently linked components: 1. DMG (dimyristoylglycerol): Lipid anchoring group-a diacylglycerol with two C14 chains, providing moderate membrane anchorage; its short-chain, high-fluidity characteristics enable faster dissociation of PEG-lipids from nanoparticle surfaces, facilitating endosomal escape and cellular uptake. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing steric separation between the lipid surface and the targeting ligand. 3. Asp6 peptide: Targeting/functional ligand-the Asp6 peptide consists of six aspartic acid residues, exhibiting high affinity for bone tissue (especially hydroxyapatite in the bone matrix), enabling bone-targeted delivery.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.