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Dusigitumab

(Synonyms: MEDI 573)
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Dusigitumab is a fully human IgG2λ monoclonal antibody that targets IGF-1 and IGF-2 with picomolar binding affinity. Dusigitumab blocks IGF-1 and IGF-2-induced phosphorylation of IGF-1R as well as activation of IR-A, thereby inhibiting the activation of downstream signaling pathways. Dusigitumab is applicable to research related to advanced solid tumors and hormone receptor-positive metastatic breast cancer.

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  • Pureté: 96.37%
  • CAS No.: 1204390-13-5
  • Masse moléculaire:144.24 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Dusigitumab
  • Experimental Validation Results for Dusigitumab
  • Experimental Validation Results for Dusigitumab
  • Dusigitumab Chemical Structure
    Dusigitumab Chemical Structure
CAS No.: 1204390-13-5
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Dusigitumab Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG2 lambda

  • 1/16

    Immobilized IGF-I/IGF-1 Protein, Human can bind Dusigitumab. The EC50 for this effect is 145.7 ng/mL.

  • 1/16

    Flow cytometric analysis of 1X106 HepG2 cells with Dusigitumab (HY-P99867, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 lambda (HY-P991206, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).

  • Dusigitumab Chemical Structure
    1/16
  • Dusigitumab
  • Immobilized IGF-I/IGF-1 Protein, Human can bind Dusigitumab. The EC50 for this effect is 145.7 ng/mL.
  • Flow cytometric analysis of 1X106 HepG2 cells with Dusigitumab (HY-P99867, red). Cells were fixed with 4% paraformaldehyde. Then stained with the primary antibody at 1/200 dilution for an hour at 4℃. AF 488-conjugated AffiniPure Goat Anti-Human IgG H&L (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Human IgG2 lambda (HY-P991206, blue) was used as the isotype control, cells without incubation with primary antibody were used as the unlabeled control (black).