(E)-C-HDMAPP ammonium
(E)-C-HDMAPP ammonium, is a potent phosphoantigen in ammonium form as well as a pyrophosphonate form of (E)-HDMAPP. (E)-C-HDMAPP is also an effective activator of γδ-T cells, induces T-cell stimulatory responses in vitro (EC50=0.91 nM for TNF-α release).
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- CAS No.: 933030-60-5
- Formule: C6H23N3O7P2
- Masse moléculaire:311.21
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
IC50 & Target
[1]|
TNFRSF1A |
In Vitro
(E)-C-HDMAPP (compound 5E) (2 μM) increases the release of TNF-α in primary polyclonal human Vγ9Vδ2 T-cell with stimulating bioactivity[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nonhuman Primate Model in Cynomolgus[1]
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Dosage:0.02 mg/kg, 0.1 mg/kg, 0.5 mg/kg, 2.5 mg/kg, 5 mg/kg, and 10 mg/kg
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Administration:Intravenous injection; once with daily s.c. low doses IL-2 to sustain γδ-T-cell proliferation, for 15 days
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Result:Significantly increased γδ-cells in vivo at 0.02 mg/kg. Reached maximal effect at 5 mg/kg and 10 mg/kg.
Chemical Information
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CAS No. 933030-60-5
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Masse moléculaire 311.21
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Formule C6H23N3O7P2
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SMILES
OC/C(C)=C/CCP(OP(O)(O)=O)(O)=O.N.N.N
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
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- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(E)-C-HDMAPP ammonium Related Classifications
HY-134950 Related Classifications
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