EG36
EG36 is a selective E. coli DnaK inhibitor that inhibits DnaK ATPase activity at a concentration of 100 μM. EG36 directly binds to the nucleotide-binding domain (NBD) of E. coli DnaK by disrupting the DnaK-DnaJ interaction. EG36 can be used for research on bacterial infectious diseases.
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- CAS No.: 2215779-34-1
- Formule: C37H41FN4O4
- Masse moléculaire:624.74
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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HSP70 |
EG36 (50-200 μM) inhibits DnaJ-GrpE-stimulated ATPase activity of purified E. coli DnaK in a dose-dependent manner, with measurable inhibition at 50, 100, and 200 μM, and enhanced inhibition with increasing DnaJ concentrations[1].
EG36 directly binds to the isolated nucleotide-binding domain of E. coli DnaK and inhibits its inherent ATPase activity[1].
EG36 does not act as a general Hsp inhibitor, as it does not alter the ATPase activity or thermal stability of bacterial HtpG[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2215779-34-1
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Masse moléculaire 624.74
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Formule C37H41FN4O4
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SMILES
COC1=CC=CC=C1N2CCC(CN3CCOC4=C(CC5=CC(C(N(CC3)C)=O)=CC=C5)C=C(C=C4)C6=CN=C(C=C6)F)(CC2)O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EG36 Related Classifications
HY-181810 Related Classifications
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