Elgodipine
Elgodipine (IQB-875 free base) is an orally active dihydropyridine calcium antagonist and an antianginal compound. Elgodipine inhibits both T- and L-type calcium channels (IC50: 32 and 2.3 nM). Elgodipine lowers systemic vascular resistance and improves systolic cardiac function.
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- CAS No.: 119413-55-7
- Formule: C29H33FN2O6
- Masse moléculaire:524.58
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[2]|
T-type calcium channel 32 nM (IC50) |
L-type calcium channel 2.3 nM (IC50) |
Chemical Information
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CAS No. 119413-55-7
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Masse moléculaire 524.58
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Formule C29H33FN2O6
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SMILES
O=C(C1=C(C)NC(C)=C(C(OC(C)C)=O)C1C2=C3OCOC3=CC=C2)OCCN(CC4=CC=C(F)C=C4)C
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Synonyms
IQB-875 free base
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Kuhn A, et al. Hemodynamic and antiischemic effects of intravenous elgodipine, a new dihydropyridine calcium channel blocker, in patients with chronic stable angina. Cardiovasc Drugs Ther. 1995 Aug;9(4):595-600. [Content Brief]
[2]. Lepretre N, et al. Electrophysiological and radioligand binding studies of elgodipine and derivatives in portal vein myocytes. J Pharmacol Exp Ther. 1994 Dec;271(3):1209-15. [Content Brief]
[3]. Acharya DU, et al. Anti-ischaemic and haemodynamic effects of elgodipine, a potent new generation calcium antagonist, in chronic stable angina. Eur Heart J. 1994 May;15(5):665-71. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Elgodipine Related Classifications
HY-126401 Related Classifications
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