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Cat. No.: HY-10777

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EMD 495235

EMD 495235 is a potent and orally active coagulation factor Xa inhibitor with an IC₅₀ of 5.5 nM and a K_i of 6.8 nM. EMD 495235 shows anticoagulant activities.

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CAS No.: 811811-33-3
Formule: C₂₀H₂₂ClN₃O₅S
Masse moléculaire:451.92

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

EMD 495235 Chemical Structure

CAS No.: 811811-33-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

EMD 495235 is a potent and orally active coagulation factor Xa inhibitor with an IC₅₀ of 5.5 nM and a K_i of 6.8 nM. EMD 495235 shows anticoagulant activities^[1].

IC₅₀ & Target

IC50: 5.5 nM (factor Xa)^[1].
Ki: 6.8 nM (human factor Xa)^[1].

In Vivo

EMD 495235 is characterized by rapid absorption from the gastrointestinal tract, plasma elimination half-lives of 0.57-2.3 h, a clearance between 0.25 and 1.3L/h/kg and absolute bioavailability of 60-80% in Wistar rats, Beagle dogs and Cynomolgus monkeys^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 811811-33-3
Masse moléculaire 451.92
Formule C₂₀H₂₂ClN₃O₅S
SMILES

ClC1=CC=C(C(N[C@H](COC)C(NC2=CC=C(N3C(COCC3)=O)C(C)=C2)=O)=O)S1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Werner W K R Mederski, et al. Chlorothiophenecarboxamides as P1 surrogates of inhibitors of blood coagulation factor Xa. Bioorg Med Chem Lett. 2004 Dec 6;14(23):5817-22. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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