Erzotabart
Based on 1 Customer Validation
Erzotabart is an IgG1-kappa, anti-CD38 (ADP-ribosyl cyclase 1, cyclic ADP-ribose hydrolase 1, cADPr hydrolase 1, cADPR1) Homo sapiens monoclonal antibody. Erzotabart shows antineoplastic activity.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.00%
- CAS No.: 2430792-01-9
- Masse moléculaire:145.056 kDa
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Human IgG1 kappa
Human
CD38
Erzotabart targets cell surface glycoprotein CD-38 and carries the E430G mutation. Erzotabart promotes antibody hexamer formation through the E430G mutation in the Fc segment, and exhibits immunomodulating and antineoplastic activities[2].
Erzotabart induces complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), trogocytosis, inhibits the cyclase activity of CD38, and increases the hydrolase activity with EC50s of 0.044 µg/mL, 0.29 ng/mL, 2.719-5.779 ng/mL, 8.79 ng/mL, 0.419 µg/mL and 0.335 µg/mL, respectively[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Ly12638 xenograft mouse models[3]
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Dosage:0.1-10 mg/kg
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Administration:iv, once weekly for 3 weeks
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Result:Inhibited tumor growth.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Human IgG1 kappa
ELISA, FACS, Functional assay
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Loaded Erzotabart on AHC2 biosensor, can bind CD38 Protein, Human (HEK293, C-His, HY-P70731A) with an affinity constant of 1.209E-09 M as determined in BLI assay. -
Flow Cytometry analysis of Raji cells labelling CD38 (red) with Erzotabart (anti-CD38) (HY-P990037). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.
Chemical Information
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CAS No. 2430792-01-9
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Appearance Liquid
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Masse moléculaire 145.056 kDa
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Color Colorless to light yellow
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SMILES
[Erzotabart]
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Synonyms
GEN3014
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Livraison
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
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Fiche technique (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Erzotabart Related Classifications
HY-P990037 Related Classifications
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