F-17
F-17 is a potential inhibitor of virulence factor. F-17 shows very significant inhibitory effect on biofilm, elastase, pyocyanin, and swarming motility. F-17 also shows a good binding effect on LasR and PqsR. F-17 has no obvious cytotoxicity.
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- CAS No.: 1572464-22-2
- Formule: C17H15BrO4
- Masse moléculaire:363.20
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Activité biologique
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
35.4 μM
Compound: Table 1, 4'=Br
|
Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
Antiproliferative activity against human DU145 cells after 48 hrs by MTT assay
|
[PMID: 27979593] |
| ECa-109 cell line | IC50 |
40.3 μM
Compound: Table 1, 4'=Br
|
Antiproliferative activity against human ECA109 cells after 48 hrs by MTT assay
Antiproliferative activity against human ECA109 cells after 48 hrs by MTT assay
|
[PMID: 27979593] |
| HeLa | IC50 |
56.8 μM
Compound: Table 1, 4'=Br
|
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
|
[PMID: 27979593] |
| MCF7 | IC50 |
28.2 μM
Compound: Table 1, 4'=Br
|
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
|
[PMID: 27979593] |
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
-
CAS No. 1572464-22-2
-
Masse moléculaire 363.20
-
Formule C17H15BrO4
-
SMILES
O=C(OCCC1=CC=C(Br)C=C1)/C=C/C2=CC=C(O)C(O)=C2
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Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)