F3 peptide acetate
Based on 1 Customer Validation
F3 peptide acetate is a nucleolin-binding tumor-homing peptide that mediates selective uptake and internalization by tumor cells. F3 peptide acetate is a 31-amino acid fragment of human high mobility group nucleosomal protein 2 (HMGN2). F3 peptide acetate inhibits protein synthesis through ribosome inactivation. F3 peptide acetate targets the tumor vasculature. F3 peptide acetate can serve as an effective ligand to improve the druggability of macromolecular drugs or nanoparticles. F3 peptide acetate is used in research on cancers such as glioblastoma and breast cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C152H263N49O41·xC2H4O2
- Masse moléculaire:3433.02 (free base)
-
Stockage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform DNA/RNA Synthesis
More
Activité biologique
Description
In Vitro
FITC-F3 peptide acetate (10 nM; 2 h) binds to the 231-H2N cell membrane, internalizes, and translocates to the nucleus and nucleolus, colocalizing with nucleolin[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:MDA-MB-231-H2N (231-H2N) human breast cancer cells
-
Concentration:10 nM
-
Incubation Time:2 h
-
Result:Showed membrane-bound and internalized fluorescence.
Observed in the nuclei, where it co-localized with nucleolin in the nucleoli.
Nuclear localization was approximately 33.6% of the total amount internalized.
Chemical Information
-
Appearance Solid
-
Masse moléculaire 3433.02 (free base)
-
Formule C152H263N49O41·xC2H4O2
-
SMILES
O=C(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N1[C@@H](CCC1)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CO)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N2[C@@H](CCC2)C(N[C@@H](C)C(N3[C@@H](CCC3)C(N4[C@@H](CCC4)C(N[C@@H](CCCCN)C(N5[C@@H](CCC5)C(N[C@@H](CCC(O)=O)C(N6[C@@H](CCC6)C(N[C@@H](CCCCN)C(N7[C@@H](CCC7)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(N[C@@H](C)C(N8[C@@H](CCC8)C(N[C@@H](C)C(N[C@@H](CCCCN)C(N[C@@H](CCCCN)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN)N.CC(O)=O.[x]
-
Sequence
Lys-Asp-Glu-Pro-Gln-Arg-Arg-Ser-Ala-Arg-Leu-Ser-Ala-Lys-Pro-Ala-Pro-Pro-Lys-Pro-Glu-Pro-Lys-Pro-Lys-Lys-Ala-Pro-Ala-Lys-Lys
-
Sequence Shortening
KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
In Vitro:
DMSO : 25 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
F3 peptide acetate Related Classifications
HY-P10997A Related Classifications
Powered by Bioz