Fazarabine
Fazarabine (Kymarabine; Ara-AC; NSC 281272) is an orally active, blood-brain barrier permeable DNA polymerase inhibitor and antitumor agent. Fazarabine interferes with DNA synthesis via intracellular activation into a triphosphate nucleotide that directly incorporates into DNA, inducing cytotoxicity, myelosuppression, as well as moderate nausea and vomiting. Fazarabine is resistant to deamination by cytidine-deoxycytidine deaminase and undergoes spontaneous aqueous degradation. Fazarabine exerts time-dependent, broad-spectrum activity against leukemia and solid tumors. Fazarabine can be used in research related to refractory malignancies, acute leukemia, and blast-phase chronic myeloid leukemia.
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- CAS No.: 65886-71-7
- Formule: C8H12N4O5
- Masse moléculaire:244.20
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Protocole
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Description
IC50 & Target
[1]|
DNA Polymerases |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOLT-4 | IC50 |
0.1 μM
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Inhibition of clonogenic survival against human Molt-4 T-lymphoblastic leukemia cells in a 24 h in vitro clonogenic survival assay.
Inhibition of clonogenic survival against human Molt-4 T-lymphoblastic leukemia cells in a 24 h in vitro clonogenic survival assay.
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2475244 |
In Vitro
Fazarabine exhibits broad-spectrum antitumor activity against the P388 and L1210 cell lines[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 65886-71-7
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Masse moléculaire 244.20
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Formule C8H12N4O5
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SMILES
NC(N=CN1[C@H]2[C@@H](O)[C@H](O)[C@@H](CO)O2)=NC1=O
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Synonyms
Kymarabine; Ara-AC; NSC 281272
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fazarabine Related Classifications
HY-123113 Related Classifications
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Keywords
- Fazarabine
- 65886-71-7
- Kymarabine
- Ara-AC
- NSC 281272
- NSC281272
- NSC 281272
- NSC-281272
- DNA/RNA Synthesis
- L1210 cell lines
- cytidine-deoxycytidine deaminase
- P388 cell lines
- DNA polymerase
- Molt-4 human T-lymphoblastic leukemia cells
- chronic myelogenous leukemia
- acute leukemia
- cerebrospinal fluid
- murine L1210 leukemias
- blood-brain barrier
- Inhibitor
- inhibitor
- inhibit