Fosnetupitant
Based on 1 publication(s) in Google Scholar
Fosnetupitant (Pronetupitant) a methylene phosphate proagent of Netupitant. Fosnetupitant (Pronetupitant) exhibits a pKi of 9.5 for human NK1 receptor.
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- CAS No.: 1703748-89-3
- Formule: C31H35F6N4O5P
- Masse moléculaire:688.60
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Stockage:
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Fosnetupitant
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Activité biologique
Fosnetupitant (Pronetupitant) displays micromolar affinity for the 5-HT6 (pKi ～ 5.2) receptor and type L Ca2+ channels (pKi ～ 5.7) and does not bind all the other proteins investigated[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 1703748-89-3
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Appearance Solid
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Masse moléculaire 688.60
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Formule C31H35F6N4O5P
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Color White to off-white
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SMILES
O=P(OC[N+]1(C)CCN(C2=NC=C(N(C)C(C(C)(C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)C)=O)C(C4=CC=CC=C4C)=C2)CC1)([O-])O
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Synonyms
Pronetupitant
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Antiviral Res
Large-scale deep learning identifies the antiviral potential of PKI-179 and MTI-31 against coronaviruses. [Abstract]2024 Nov:231:106012. PMID: 39332537
Solvant et solubilité
DMSO : 100 mg/mL (145.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4522 mL | 7.2611 mL | 14.5222 mL | 36.3055 mL |
| 5 mM | 0.2904 mL | 1.4522 mL | 2.9044 mL | 7.2611 mL | |
| 10 mM | 0.1452 mL | 0.7261 mL | 1.4522 mL | 3.6306 mL | |
| 15 mM | 0.0968 mL | 0.4841 mL | 0.9681 mL | 2.4204 mL | |
| 20 mM | 0.0726 mL | 0.3631 mL | 0.7261 mL | 1.8153 mL | |
| 25 mM | 0.0581 mL | 0.2904 mL | 0.5809 mL | 1.4522 mL | |
| 30 mM | 0.0484 mL | 0.2420 mL | 0.4841 mL | 1.2102 mL | |
| 40 mM | 0.0363 mL | 0.1815 mL | 0.3631 mL | 0.9076 mL | |
| 50 mM | 0.0290 mL | 0.1452 mL | 0.2904 mL | 0.7261 mL | |
| 60 mM | 0.0242 mL | 0.1210 mL | 0.2420 mL | 0.6051 mL | |
| 80 mM | 0.0182 mL | 0.0908 mL | 0.1815 mL | 0.4538 mL | |
| 100 mM | 0.0145 mL | 0.0726 mL | 0.1452 mL | 0.3631 mL |
Fosnetupitant Related Classifications
HY-17615 Related Classifications
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