PDS5A - PDS5 cohesin associated factor A Gene

Also Known as PIG54; SCC112; SCC-112

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23244

About PDS5A

Cytogenetic location: 4p14 Genomic coordinates (GRCh38): 4:39,822,863-39,977,911 (from NCBI)

This gene has 10 transcripts (splice variants), 226 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 18.1), lymph node (RPKM 17.1) and 25 other tissues.

Summary

The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during Mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

PDS5A Products (2)

mRNA	Protein	Name
NM_001100399.2	NP_001093869.1	sister chromatid cohesion protein PDS5 homolog A isoform 1
NM_001100400.2	NP_001093870.1	sister chromatid cohesion protein PDS5 homolog A isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15837422	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in mitotic sister chromatid cohesion	IPI IPI: Inferred from physical interaction	21111234	GOA
involved in negative regulation of DNA replication	IMP IMP: Inferred from mutant phenotype	19907496	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in chromatin	IDA IDA: Inferred from direct assay	16682347	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
sister chromatid cohesion protein PDS5 homolog A	PDS5, regulator of cohesion maintenance, homolog A

PDS5A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	PDS5A	Q29RF7	STAG2	Homo sapiens	Q8N3U4	Anti Bait CoIP	17113138
Intra	PDS5A	Q29RF7	STAG2	Homo sapiens	Q8N3U4	Anti Bait CoIP	15855230
Intra	PDS5A	Q29RF7	STAG1	Homo sapiens	Q8WVM7	Anti Bait CoIP	17113138
Intra	PDS5A	Q29RF7	STAG1	Homo sapiens	Q8WVM7	Anti Bait CoIP	15855230
Intra	PDS5A	Q29RF7	CDCA5	Homo sapiens	Q96FF9	Anti Bait CoIP	21111234
Intra	PDS5A	Q29RF7	SMC3	Homo sapiens	Q9UQE7	Anti Bait CoIP	17113138
Intra	PDS5A	Q29RF7	SMC3	Homo sapiens	Q9UQE7	Anti Bait CoIP	15855230
Intra	PDS5A	Q29RF7	RAD21	Homo sapiens	O60216	Anti Bait CoIP	17113138
Intra	PDS5A	Q29RF7	RAD21	Homo sapiens	O60216	Anti Bait CoIP	17112726
Intra	PDS5A	Q29RF7	RAD21	Homo sapiens	O60216	Anti Bait CoIP	15855230

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cornelia De Lange Syndrome	De Lange Syndrome Brachmann De Lange Syndrome Brachmann-De Lange Syndrome Cdls Bdls Typus Degenerativus Amstelodamensis
Roberts-Sc Phocomelia Syndrome	Roberts Syndrome Sc Phocomelia Syndrome RBS Long Bone Deficiencies Associated With Cleft Lip-Palate Sc Pseudothalidomide Syndrome Appelt-Gerken-Lenz Syndrome Pseudothalidomide Syndrome Tetraphocomelia-Cleft Palate Syndrome Hypomelia Hypotrichosis Facial Hemangioma Syndrome Roberts Syndrome/Sc Phocomelia Roberts Tetraphocomelia Syndrome Sc Syndrome Sc Phocomelia Sc Disease Sc Hemoglobin Sc Disease
Somatization Disorder	Somatoform Disorders Briquet'S Disorder Polysomatising Disorder Somatisation Disorder Somatoform Disorder
Warsaw Breakage Syndrome	WABS WBRS
Chronic Atrial And Intestinal Dysrhythmia	CAID Caid Syndrome Cohesinopathy Affecting Heart And Gut Rhythm Chronic Atrial Intestinal Dysrhythmia Syndrome Chronic Atrial And Intestinal Dysrhythmia Syndrome Chronic Atrial Dysrhythmia-Intestinal Motility Disorder Dysrhythmia, Atrial And Intestinal, Chronic
Familial Isolated Trichomegaly	Long Eyelashes Tcmgly
Alpha-Thalassemia	Alpha Thalassemia Alpha Thalassaemia Alpha Plus Thalassemia Thalassemia, Alpha- Thalassemias, Alpha- A-Thalassemia Α-Thalassemia A-THAL Thalassemia Alpha Thalassaemia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS10291	PDS5A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PDS5A	RGD	RGD:1307094
Bos taurus	PDS5A	VGNC	VGNC:32717
Felis catus	PDS5A	VGNC	VGNC:64097
Macaca mulatta	PDS5A	VGNC	VGNC:100261
Canis familiaris	PDS5A	VGNC	VGNC:44392
Mus musculus	PDS5A	MGD	MGI:1918771
Others	PDS5A	NCBI