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NCS1 - neuronal calcium sensor 1 Gene

Also Known as FLUP; FREQ

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23413

About NCS1

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:130,172,404-130,237,303 (from NCBI)

This gene has 3 transcripts (splice variants), 120 orthologues and 14 paralogues. Biased expression in brain (RPKM 60.4), esophagus (RPKM 14.4) and 11 other tissues.

Summary

This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for Calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

NCS1 Products (2)

mRNA	Protein	Name
NM_001128826.2	NP_001122298.1	neuronal calcium sensor 1 isoform 2
NM_014286.4	NP_055101.2	neuronal calcium sensor 1 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12783849	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	12783849	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	12783849	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCS1 Protein Structure

EF-hand_1

EF-hand_7

0
100
190 a.a.

Protein Preferred Names	Protein Names
neuronal calcium sensor 1	frequenin homolog

NCS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	NCS1	P62166	NBL1	Homo sapiens	P41271	Validated Y2H	25416956
Intra	NCS1	P62166	CEP89	Homo sapiens	Q96ST8-3	Validated Y2H	32296183
Intra	NCS1	P62166	CEP89	Homo sapiens	Q96ST8-3	MAPPIT	32296183
Intra	NCS1	P62166	CTAG1A	Homo sapiens	P78358	Y2H Prey Pooling	32296183
Intra	NCS1	P62166	CTAG1A	Homo sapiens	P78358	Validated Y2H	32296183
Intra	NCS1	P62166	CTAG1A	Homo sapiens	P78358	Y2H Array	32296183
Intra	NCS1	P62166	MIEF2	Homo sapiens	Q96C03-3	Validated Y2H	32296183
Intra	NCS1	P62166	SFTPA2	Homo sapiens	Q8IWL1	Validated Y2H	32296183
Intra	NCS1	P62166	SFTPA2	Homo sapiens	Q8IWL1	Y2H Array	32296183
Intra	NCS1	P62166	SFTPA2	Homo sapiens	Q8IWL1	Y2H Prey Pooling	32296183
Intra	NCS1	P62166	LY6G6D	Homo sapiens	O95868	Y2H Prey Pooling	32296183
Intra	NCS1	P62166	LY6G6D	Homo sapiens	O95868	Y2H Array	32296183
Intra	NCS1	P62166	OXER1	Homo sapiens	Q8TDS5	Validated Y2H	32296183
Intra	NCS1	P62166	OXER1	Homo sapiens	Q8TDS5	Y2H Array	32296183
Intra	NCS1	P62166	OXER1	Homo sapiens	Q8TDS5	Y2H Prey Pooling	32296183
Intra	NCS1	P62166	SIGLEC9	Homo sapiens	Q9Y336	Validated Y2H	32296183
Intra	NCS1	P62166	CREM	Homo sapiens	Q03060-25	Y2H Array	32296183
Intra	NCS1	P62166	CREM	Homo sapiens	Q03060-25	Y2H Prey Pooling	32296183
Intra	NCS1	P62166	CREM	Homo sapiens	Q03060-25	Validated Y2H	32296183
Intra	NCS1	P62166	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
Intra	NCS1	P62166	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	NCS1	P62166	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	NCS1	P62166	a0a1u9x8x8_human	Homo sapiens	A0A1U9X8X8	Y2H Prey Pooling	32296183
Intra	NCS1	P62166	a0a1u9x8x8_human	Homo sapiens	A0A1U9X8X8	Y2H Array	32296183
Intra	NCS1	P62166	RNASEH1	Homo sapiens	O60930	Y2H Array	32296183
Intra	NCS1	P62166	RNASEH1	Homo sapiens	O60930	Y2H Prey Pooling	32296183
Intra	NCS1	P62166	PRDM4	Homo sapiens	Q9UKN5	Y2H Array	32296183
Intra	NCS1	P62166	PRDM4	Homo sapiens	Q9UKN5	Y2H Prey Pooling	32296183
Intra	NCS1	P62166	PRDM4	Homo sapiens	Q9UKN5	Validated Y2H	32296183
Intra	NCS1	P62166	C1QTNF2	Homo sapiens	Q9BXJ5	Y2H Prey Pooling	32296183
Intra	NCS1	P62166	C1QTNF2	Homo sapiens	Q9BXJ5	Y2H Array	32296183
Intra	NCS1	P62166	C1QTNF2	Homo sapiens	Q9BXJ5	Validated Y2H	32296183
Intra	NCS1	P62166	SPRED2	Homo sapiens	Q7Z698	Y2H Prey Pooling	32296183
Intra	NCS1	P62166	SPRED2	Homo sapiens	Q7Z698	Validated Y2H	32296183
Intra	NCS1	P62166	SPRED2	Homo sapiens	Q7Z698	Y2H Array	32296183
Intra	NCS1	P62166	SPP1	Homo sapiens	P10451	Y2H Array	32296183
Intra	NCS1	P62166	SPP1	Homo sapiens	P10451	Y2H Prey Pooling	32296183
Intra	NCS1	P62166	DTX2	Homo sapiens	Q86UW9	Validated Y2H	25416956
Intra	NCS1	P62166	DTX2	Homo sapiens	Q86UW9	Validated Y2H	32296183
Intra	NCS1	P62166	DTX2	Homo sapiens	Q86UW9	Y2H Array	25416956
Intra	NCS1	P62166	DTX2	Homo sapiens	Q86UW9	Y2H Array	32296183
Intra	NCS1	P62166	DTX2	Homo sapiens	Q86UW9	Y2H Pooling	16189514
Intra	NCS1	P62166	DTX2	Homo sapiens	Q86UW9	Y2H Prey Pooling	32296183
Intra	NCS1	P62166	DTX2	Homo sapiens	Q86UW9	Y2H	21516116
Intra	NCS1	P62166	ZC3H10	Homo sapiens	Q96K80	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

NCS1 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P86980	NCS1 Antibody (YA6673)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Wolfram Syndrome	Didmoad Syndrome Didmoad Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Wfs Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, And Deafness Didmoadud Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Deafness Syndrome Diabetes Insipidus-Diabetes Mellitus-Optic Atrophy-Hearing Loss Syndrome
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Wolfram Syndrome 2	WFS2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-N2037C	(S)-Higenamine hydrobromide		97.85%	Unkown
HY-122579	IGS-1.76	Inhibitor	98.57%	Unkown
HY-N2037B	(S)-Higenamine		/	Unkown
HY-RS09102	NCS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-121503	FD44		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NCS1	RGD	RGD:68417
Canis familiaris	NCS1	VGNC	VGNC:43667
Bos taurus	NCS1	VGNC	VGNC:31928
Felis catus	NCS1	VGNC	VGNC:63744
Mus musculus	NCS1	MGD	MGI:109166
Others	NCS1	NCBI