Brd7 - bromodomain containing 7 Gene

Also Known as BP75; CELTIX1; Ptpn13ip

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26992

About Brd7

Chromosome 8: 89,057,667-89,088,822 reverse strand.GRCm39:CM001001.3

This gene has 7 transcripts (splice variants), 223 orthologues, 2 paralogues and is associated with 37 phenotypes. Ubiquitous expression in CNS E11.5 (RPKM 13.7), CNS E14 (RPKM 11.2) and 28 other tissues.

Summary

Enables transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; positive regulation of histone acetylation; and regulation of transcription, DNA-templated. Predicted to act upstream of or within Wnt signaling pathway. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; lung; retina; and tooth. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human BRD7 (bromodomain containing 7). [provided by Alliance of Genome Resources, Apr 2022]

Brd7 Products (6)

mRNA Protein Name
NM_001377014.1 NP_001363943.1 bromodomain-containing protein 7 isoform 3
NM_001377017.1 NP_001363946.1 bromodomain-containing protein 7 isoform 2
NM_001377015.1 NP_001363944.1 bromodomain-containing protein 7 isoform 4
NM_001377016.1 NP_001363945.1 bromodomain-containing protein 7 isoform 1
NM_001377013.1 NP_001363942.1 bromodomain-containing protein 7 isoform 2
NM_012047.3 NP_036177.1 bromodomain-containing protein 7 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
10526152 MGI
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
19909775 MGI
Cellular Component GO Annotation Evidence Références Source
part of SWI/SNF superfamily-type complex IDA
IDA: Inferred from direct assay
24335282 MGI
located in nucleus IPI
IPI: Inferred from physical interaction
10526152 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Brd7 Protein Structure

Bromo_brd7_like

Bromo_brd7_like: cd05513 (134 - 231)

DUF3512

DUF3512: pfam12024 (297 - 484)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 651 a.a.
Protein Preferred Names Protein Names

bromodomain-containing protein 7

  • 75 kDa bromodomain protein

  • bromodomain protein 75 kDa

  • protein tyrosine phosphatase, non-receptor type 13 interacting protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-114322 VZ185 Inhibitor 99.95% Unkown
HY-100352 BI-9564 Inhibitor 98.96% Unkown
HY-110374 NVS-CECR2-1 Inhibitor 99.40% Unkown
HY-100517 TP-472 Inhibitor 99.54% Unkown
HY-149420 BRD7-IN-2 Inhibitor 99.29% Unkown
HY-101121 NI-42 Inhibitor 99.53% Unkown
HY-116227 (2S,3R)-LP99 Inhibitor 99.4% Unkown
HY-111905A BRD7-IN-1 free base Inhibitor / Unkown
HY-149806 Bromodomain IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Brd7 NCBI NCBI:29117