1. PROTAC
    Epigenetics
  2. PROTAC
    Epigenetic Reader Domain
  3. VZ185

VZ185 

Cat. No.: HY-114322 Purity: >97.0%
Handling Instructions

VZ185 is a potent, fast, and selective dual BRD7/9 PROTAC degrader with DC50s of 4.5 and 1.8 nM, respectively.

For research use only. We do not sell to patients.

VZ185 Chemical Structure

VZ185 Chemical Structure

CAS No. : 2306193-61-1

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1 mg USD 393 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

VZ185 is a potent, fast, and selective dual BRD7/9 PROTAC degrader with DC50s of 4.5 and 1.8 nM, respectively.

IC50 & Target[1]

BRD7

4.5 nM (DC50)

BRD9

1.8 nM (DC50)

Molecular Weight

995.21

Formula

C₅₃H₆₇FN₈O₈S

CAS No.

2306193-61-1

SMILES

O=C([[email protected]]1N(C([[email protected]@H](NC(C2(F)CC2)=O)C(C)(C)C)=O)C[[email protected]](O)C1)NCC3=CC=C(C4=C(C)N=CS4)C=C3OCCCCCN5CCN(CC6=C(OC)C=C(C(C7=CC=NC=C87)=CN(C)C8=O)C=C6OC)CC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >97.0%

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Keywords:

VZ185VZ 185VZ-185PROTACEpigenetic Reader DomainProteolysis-targeting chimeraInhibitorinhibitorinhibit

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