BRD7 - bromodomain containing 7 Gene

Also Known as BP75; NAG4; CELTIX1; SMARCI1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29117

About BRD7

Cytogenetic location: 16q12.1 Genomic coordinates (GRCh38): 16:50,315,957-50,368,988 (from NCBI)

This gene has 7 transcripts (splice variants), 220 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 21.8), spleen (RPKM 16.7) and 25 other tissues.

Summary

This gene encodes a protein which is a member of the bromodomain-containing protein family. The product of this gene has been identified as a component of one form of the SWI/SNF chromatin remodeling complex, and as a protein which interacts with p53 and is required for p53-dependent oncogene-induced senescence which prevents tumor growth. Pseudogenes have been described on chromosomes 2, 3, 6, 13 and 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

BRD7 Products (12)

mRNA	Protein	Name
NM_013263.5	NP_037395.2	bromodomain-containing protein 7 isoform 2
XM_017023180.2	XP_016878669.1	bromodomain-containing protein 7 isoform X6
NM_001173984.3	NP_001167455.1	bromodomain-containing protein 7 isoform 1
XM_011523046.4	XP_011521348.1	bromodomain-containing protein 7 isoform X1
XM_011523048.3	XP_011521350.1	bromodomain-containing protein 7 isoform X3
XM_047434006.1	XP_047289962.1	bromodomain-containing protein 7 isoform X7
XM_011523047.3	XP_011521349.1	bromodomain-containing protein 7 isoform X2
XM_047434007.1	XP_047289963.1	bromodomain-containing protein 7 isoform X8
XM_011523050.4	XP_011521352.1	bromodomain-containing protein 7 isoform X10
XM_047434008.1	XP_047289964.1	bromodomain-containing protein 7 isoform X9
XM_017023179.2	XP_016878668.1	bromodomain-containing protein 7 isoform X5
XM_011523049.3	XP_011521351.1	bromodomain-containing protein 7 isoform X4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables histone binding	IDA IDA: Inferred from direct assay	12489984	GOA
enables lysine-acetylated histone binding	IDA IDA: Inferred from direct assay	16265664	GOA
enables p53 binding	IPI IPI: Inferred from physical interaction	20228809	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12489984	GOA
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	20228809	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	20228809	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	16265664	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16265664	GOA
involved in negative regulation of G1/S transition of mitotic cell cycle	IDA IDA: Inferred from direct assay	16265664	GOA
involved in regulation of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	20228809	GOA
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12489984	GOA
involved in transcription initiation-coupled chromatin remodeling	IMP IMP: Inferred from mutant phenotype	20228809	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	11025449	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BRD7 Protein Structure

Bromodomain

DUF3512

0
100
200
300
400
500
600
651 a.a.

Protein Preferred Names	Protein Names
bromodomain-containing protein 7	75 kDa bromodomain protein protein CELTIX-1

BRD7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	BRD7	Q9NPI1	TP53	Homo sapiens	P04637	Anti Bait CoIP	20228809
Intra	BRD7	Q9NPI1	TP53	Homo sapiens	P04637	Y2H	20228809
Intra	BRD7	Q9NPI1	TP53	Homo sapiens	P04637	Pull Down	20228809
Intra	BRD7	Q9NPI1	EP300	Homo sapiens	Q09472	Pull Down	20228809
Intra	BRD7	Q9NPI1	EP300	Homo sapiens	Q09472	Anti Bait CoIP	20228809

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Endometrial Adenosquamous Carcinoma	Adenosquamous Carcinoma Of Endometrium Adenosquamous Carcinoma Of The Endometrium Endometrial Adenosquamous Cancer Endometrial Adenosquamous Cell Carcinoma
Neurilemmomatosis	Schwannomatosis Neurofibromatosis Type 3 Nf3 Neurilemmomatosis Congenital Cutaneous Neurinomatosis Congenital Cutaneous Neurilemmomatosis Multiple Neurilemmomas Multiple Schwannomas Neurilemmomatosis, Congenital Cutaneous Schwannomatosis 1 Neurofibromatosis 3 Mixed Central And Peripheral Neurofibromatosis Nf3 - [Neurofibromatosis Type 3]
Granular Cell Carcinoma	Granular Cell Cancer Granular Cell Adenocarcinoma
Malignant Granular Cell Myoblastoma	Malignant Granular Cell Tumor Granular Cell Tumor, Malignant Malignant Granular Cell Neoplasm
Rhabdoid Cancer	Rhabdoid Tumor Malignant Rhabdoid Tumor Malignant Rhabdoid Tumour Rhabdoid Sarcoma Rhabdoid Tumor Predisposition Syndrome 1 Rhabdoid Tumor Predisposition Syndrome 2 Atypical Teratoid Rhabdoid Tumor Brain Tumor, Posterior Fossa, Of Infancy, Familial Atypical Teratoid/Rhabdoid Tumor

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114322	VZ185	Inhibitor	99.95%	Unkown
HY-100352	BI-9564	Inhibitor	98.96%	Unkown
HY-110374	NVS-CECR2-1	Inhibitor	99.40%	Unkown
HY-100517	TP-472	Inhibitor	99.54%	Unkown
HY-149420	BRD7-IN-2	Inhibitor	99.29%	Unkown
HY-101121	NI-42	Inhibitor	99.53%	Unkown
HY-116227	(2S,3R)-LP99	Inhibitor	99.4%	Unkown
HY-111905A	BRD7-IN-1 free base	Inhibitor	/	Unkown
HY-149806	Bromodomain IN-2	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BRD7	RGD	RGD:1309891
Felis catus	BRD7	VGNC	VGNC:60169
Bos taurus	BRD7	VGNC	VGNC:26560
Mus musculus	BRD7	MGD	MGI:1349766
Canis familiaris	BRD7	VGNC	VGNC:38521
Macaca mulatta	BRD7	VGNC	VGNC:103794
Others	BRD7	NCBI