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  3. TP-472

TP-472 

Cat. No.: HY-100517
Handling Instructions

TP-472 is a selective BRD9 inhibitor, with a Kd of 33 nM.

For research use only. We do not sell to patients.

TP-472 Chemical Structure

TP-472 Chemical Structure

CAS No. : 2079895-62-6

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Description

TP-472 is a selective BRD9 inhibitor, with a Kd of 33 nM[1][2].

IC50 & Target

Kd: 33 nM (BRD9)[1]

In Vitro

TP-472 has a high potency for BRD9 (Kd= 33 nM) and BRD7 (Kd= 0.34 μM), with >30-fold selectivity over other Brds[1].
TP-472 (1 µM, 3 µM; 24-216 hours) yields concentration-dependent growth defects in ESCs[2].

Cell Viability Assay[2]

Cell Line: ESCs
Concentration: 1 µM, 3 µM
Incubation Time: 24 hours, 72 hours, 120 hours, 168 hours, 216 hours
Result: Yields concentration-dependent growth defects in ESCs.
Molecular Weight

333.38

Formula

C₂₀H₁₉N₃O₂

CAS No.

2079895-62-6

SMILES

O=C(C)C1=CC(C2=C(C)C=CC(C(NC3CC3)=O)=C2)=C4N=CC=CN41

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

TP-472TP472TP 472Epigenetic Reader DomainBRD9BRD9-BDInhibitorinhibitorinhibit

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TP-472
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