STOML2 - stomatin like 2 Gene

Also Known as SLP-2; HSPC108

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 30968

About STOML2

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:35,099,776-35,103,195 (from NCBI)

This gene has 5 transcripts (splice variants), 216 orthologues and 4 paralogues. Ubiquitous expression in kidney (RPKM 27.8), heart (RPKM 26.8) and 25 other tissues.

Summary

Enables GTPase binding activity and cardiolipin binding activity. Involved in several processes, including inorganic cation transmembrane transport; positive regulation of cardiolipin metabolic process; and positive regulation of mitochondrial DNA replication. Located in membrane raft; mitochondrial inner membrane; and mitochondrial intermembrane space. Is extrinsic component of plasma membrane. Colocalizes with several cellular components, including COP9 signalosome; T cell receptor complex; and immunological synapse. [provided by Alliance of Genome Resources, Apr 2022]

STOML2 Products (4)

mRNA Protein Name
NM_001287031.2 NP_001273960.1 stomatin-like protein 2, mitochondrial isoform b
NM_001287032.1 NP_001273961.1 stomatin-like protein 2, mitochondrial isoform c
NM_001287033.2 NP_001273962.1 stomatin-like protein 2, mitochondrial isoform d
NM_013442.3 NP_038470.1 stomatin-like protein 2, mitochondrial isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables GTPase binding IPI
IPI: Inferred from physical interaction
24337748 GOA
enables T cell receptor binding IDA
IDA: Inferred from direct assay
18641330 GOA
enables cardiolipin binding IDA
IDA: Inferred from direct assay
21746876 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17121834 GOA
Biological Process GO Annotation Evidence Références Source
acts upstream of or within T cell receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
18641330 GOA
involved in intracellular calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
19944461 GOA
involved in mitochondrion organization IMP
IMP: Inferred from mutant phenotype
21746876 GOA
involved in protein complex oligomerization IDA
IDA: Inferred from direct assay
17121834 GOA
Cellular Component GO Annotation Evidence Références Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
18641330 GOA
located in immunological synapse IDA
IDA: Inferred from direct assay
22623988 GOA
located in membrane raft IDA
IDA: Inferred from direct assay
18641330 GOA
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
17121834 GOA
located in mitochondrial intermembrane space IDA
IDA: Inferred from direct assay
17121834 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
22623988 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STOML2 Protein Structure

Band_7

Band_7: SPFH domain / Band 7 family (40 - 209)

  • 0
  • 100
  • 200
  • 300
  • 356 a.a.
Protein Preferred Names Protein Names

stomatin-like protein 2, mitochondrial

  • EPB72-like 2

STOML2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
STOML2 Q9UJZ1 ATXN2 Homo sapiens Q99700-5
Validated Y2H
32814053
Intra
STOML2 Q9UJZ1 ATXN2 Homo sapiens Q99700-5
Y2H Array
32814053
Intra
STOML2 Q9UJZ1 ATXN2 Homo sapiens Q99700-5
Y2H Pooling
32814053
Intra
STOML2 Q9UJZ1 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
STOML2 Q9UJZ1 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
STOML2 Q9UJZ1 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
STOML2 Q9UJZ1 PEX1 Homo sapiens O43933
Validated Y2H
32814053
Intra
STOML2 Q9UJZ1 PEX1 Homo sapiens O43933
Y2H Array
32814053
Intra
STOML2 Q9UJZ1 PEX1 Homo sapiens O43933
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

STOML2 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P81975 SLP2 Antibody (YA1720) WB, ICC/IF, IP, FC Human, Mouse, Rat
HY-P81975A SLP2 Antibody (YA1720)(PBS only) WB, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Macroglobulinemia

  • Primary Macroglobulinemia

  • Waldenstrom Macroglobulinemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-122671 OB-1 Inhibitor 99.40% Unkown
HY-RS13950 STOML2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-122671S OB-1-d3 Control / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus STOML2 VGNC VGNC:35411
Rattus norvegicus STOML2 RGD RGD:1308285
Macaca mulatta STOML2 VGNC VGNC:78116
Mus musculus STOML2 MGD MGI:1913842
Felis catus STOML2 VGNC VGNC:65794
Others STOML2 NCBI