NFE2L1 - NFE2 like bZIP transcription factor 1 Gene

Also Known as NRF1; NRF-1; TCF11; LCR-F1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4779

About NFE2L1

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,048,359-48,061,545 (from NCBI)

This gene has 23 transcripts (splice variants), 277 orthologues and 3 paralogues. Ubiquitous expression in heart (RPKM 133.9), kidney (RPKM 94.6) and 24 other tissues.

Summary

This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008]

NFE2L1 Products (3)

mRNA Protein Name
NM_001330261.2 NP_001317190.1 endoplasmic reticulum membrane sensor NFE2L1 isoform 2
NM_001330262.2 NP_001317191.1 endoplasmic reticulum membrane sensor NFE2L1 isoform 3
NM_003204.3 NP_003195.1 endoplasmic reticulum membrane sensor NFE2L1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
15308669 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
8932385 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
20102225 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
20102225 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
8932385 GOA
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15308669 GOA
involved in regulation of odontoblast differentiation IDA
IDA: Inferred from direct assay
15308669 GOA
Cellular Component GO Annotation Evidence Références Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
24448410 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24448410 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFE2L1 Protein Structure

bZIP_Maf

bZIP_Maf: bZIP Maf transcription factor (626 - 717)

  • 0
  • 200
  • 400
  • 600
  • 772 a.a.
Protein Preferred Names Protein Names

endoplasmic reticulum membrane sensor NFE2L1

  • NF-E2-related factor 1

NFE2L1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
NFE2L1 Q14494 MAFG Homo sapiens O15525
Peptide Array
20102225
Intra
NFE2L1 Q14494 MAFG Homo sapiens O15525
BRET
37398436
Intra
NFE2L1 Q14494 MAFG Homo sapiens O15525
FRET
23661758
Intra
NFE2L1 Q14494 CREBZF Homo sapiens Q9NS37
Peptide Array
20102225
Intra
NFE2L1 Q14494 MAFF Homo sapiens Q9ULX9
FRET
23661758
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Appendix Lymphoma

  • Appendiceal Lymphoma
Ngly1-Deficiency

  • Deficiency Of N-Glycanase 1

  • Ngly1-Cddg

  • Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome

  • Ngly1 Deficiency

  • Congenital Disorder Of Deglycosylation

  • Congenital Disorder Of Glycosylation Type Iv

  • Congenital Disorder Of Deglycosylation

  • Cddg

  • Congenital Disorder Of Glycosylation Type Iv

  • Cdg1v
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-178997 NFE2L1 activator-1 98.93% Unkown
HY-RS09244 NFE2L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21165 Nfe2l1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27681 Nfe2l1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NFE2L1 VGNC VGNC:75331
Felis catus NFE2L1 VGNC VGNC:68474
Canis familiaris NFE2L1 VGNC VGNC:43772
Mus musculus NFE2L1 MGD MGI:99421
Rattus norvegicus NFE2L1 RGD RGD:1311972
Bos taurus NFE2L1 VGNC VGNC:32035
Others NFE2L1 NCBI