NFYC - nuclear transcription factor Y subunit gamma Gene

Also Known as HSM; CBFC; HAP5; CBF-C; NF-YC; H1TF2A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4802

About NFYC

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:40,691,704-40,771,603 (from NCBI)

This gene has 24 transcripts (splice variants), 209 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 9.6), heart (RPKM 9.5) and 25 other tissues.

Summary

This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

NFYC Products (7)

mRNA	Protein	Name
NM_001142587.2	NP_001136059.1	nuclear transcription factor Y subunit gamma isoform 3
NM_001142588.2	NP_001136060.1	nuclear transcription factor Y subunit gamma isoform 1
NM_001142589.2	NP_001136061.1	nuclear transcription factor Y subunit gamma isoform 4
NM_001142590.2	NP_001136062.1	nuclear transcription factor Y subunit gamma isoform 5
NM_001308114.1	NP_001295043.1	nuclear transcription factor Y subunit gamma isoform 6
NM_001308115.2	NP_001295044.1	nuclear transcription factor Y subunit gamma isoform 7
NM_014223.5	NP_055038.2	nuclear transcription factor Y subunit gamma isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15243141	GOA
contributes to RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11256944	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12401788	GOA
contributes to transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	11256944	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	23332751	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15243141	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of CCAAT-binding factor complex	IDA IDA: Inferred from direct assay	15243141	GOA
part of CCAAT-binding factor complex	IPI IPI: Inferred from physical interaction	23332751	GOA
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	11256944	GOA
located in nucleus	IDA IDA: Inferred from direct assay	15243141	GOA
part of protein-DNA complex	IDA IDA: Inferred from direct assay	11256944	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NFYC Protein Structure

CBFD_NFYB_HMF

0
100
200
300
400
458 a.a.

Protein Preferred Names	Protein Names
nuclear transcription factor Y subunit gamma	CAAT box DNA-binding protein subunit C

NFYC Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	NFYC	Q13952	NFYB	Homo sapiens	P25208	Affinity Chrom	35140242
Intra	NFYC	Q13952	NFYB	Homo sapiens	P25208	BioID	35140242
Intra	NFYC	Q13952	NFYB	Homo sapiens	P25208	Y2H Pooling	20936779
Intra	NFYC	Q13952	NFYB	Homo sapiens	P25208	Anti Tag CoIP	33961781
Intra	NFYC	Q13952	NFYA	Homo sapiens	P23511	Anti Tag CoIP	33961781
Intra	NFYC	Q13952	NFYA	Homo sapiens	P23511	Affinity Chrom	35140242
Intra	NFYC	Q13952	NFYA	Homo sapiens	P23511	BioID	35140242
Intra	NFYC	Q13952	NFYA	Homo sapiens	P23511	Y2H Pooling	20936779

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Choroid Plexus Cancer	Choroid Plexus Carcinoma Choroid Plexus Neoplasms Choroid Plexus Neoplasm Tumor Of Choroid Plexus Tumor Of The Choroid Plexus Choroid Plexus Tumor Choroid Plexus Tumors Anaplastic Choroid Plexus Papilloma Choroid Plexus Papilloma Nos Papilloma Of Choroid Plexus Plexus Choroideus Papilloma Choroid Plexus Papilloma In Fourth Ventricle Plexus Choroideus Papilloma In Fourth Ventricle
Neonatal Candidiasis	Neonatal Candida Infection Neonatal Monilia Infection Neonatal Moniliasis
Adult Acute Monocytic Leukemia	Adult Acute Monoblastic And Acute Monocytic Leukemia
Cyclosporiasis	Cyclosporosis Cyclospora Infection
Atypical Choroid Plexus Papilloma	Atypical Papilloma Of Choroid Plexus Atypical Cpp
Multiple Epiphyseal Dysplasia Due To Collagen 9 Anomaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS09273	NFYC Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NFYC	VGNC	VGNC:106416
Felis catus	NFYC	VGNC	VGNC:68492
Canis familiaris	NFYC	VGNC	VGNC:43792
Bos taurus	NFYC	VGNC	VGNC:32057
Mus musculus	NFYC	MGD	MGI:107901
Rattus norvegicus	NFYC	RGD	RGD:3173
Others	NFYC	NCBI