IP6K2 - inositol hexakisphosphate kinase 2 Gene

Also Known as PIUS; IHPK2; InsP6K2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51447

About IP6K2

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:48,688,003-48,717,221 (from NCBI)

This gene has 28 transcripts (splice variants), 267 orthologues and 6 paralogues. Ubiquitous expression in bone marrow (RPKM 16.6), skin (RPKM 16.3) and 25 other tissues.

Summary

This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

IP6K2 Products (8)

mRNA Protein Name
NM_001005909.3 NP_001005909.1 inositol hexakisphosphate kinase 2 isoform a
NM_001005910.3 NP_001005910.1 inositol hexakisphosphate kinase 2 isoform b
NM_001005911.3 NP_001005911.1 inositol hexakisphosphate kinase 2 isoform b
NM_001146178.3 NP_001139650.1 inositol hexakisphosphate kinase 2 isoform c
NM_001146179.3 NP_001139651.1 inositol hexakisphosphate kinase 2 isoform c
NM_001190316.2 NP_001177245.1 inositol hexakisphosphate kinase 2 isoform d
NM_001190317.2 NP_001177246.1 inositol hexakisphosphate kinase 2 isoform e
NM_016291.4 NP_057375.2 inositol hexakisphosphate kinase 2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables flavonoid binding IDA
IDA: Inferred from direct assay
30624931 GOA
enables inositol hexakisphosphate 5-kinase activity IDA
IDA: Inferred from direct assay
30624931 GOA
enables inositol hexakisphosphate kinase activity IDA
IDA: Inferred from direct assay
10574768 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18195352 GOA
Biological Process GO Annotation Evidence Références Source
involved in cellular response to flavonoid IMP
IMP: Inferred from mutant phenotype
30624931 GOA
involved in inositol phosphate metabolic process IDA
IDA: Inferred from direct assay
30624931 GOA
involved in negative regulation of cell growth IMP
IMP: Inferred from mutant phenotype
11337497 GOA
involved in phosphatidylinositol phosphate biosynthetic process IDA
IDA: Inferred from direct assay
10574768 GOA
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
11337497 GOA
Cellular Component GO Annotation Evidence Références Source
located in nucleus IDA
IDA: Inferred from direct assay
11502751 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IP6K2 Protein Structure

IPK

IPK: Inositol polyphosphate kinase (203 - 417)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 426 a.a.
Protein Preferred Names Protein Names

inositol hexakisphosphate kinase 2

  • ATP:1D-myo-inositol-hexakisphosphate phosphotransferase

IP6K2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
IP6K2 Q9UHH9 PGK2 Homo sapiens P07205
Anti Tag CoIP
33961781
Intra
IP6K2 Q9UHH9 PGK2 Homo sapiens P07205
Anti Tag CoIP
28514442
Intra
IP6K2 Q9UHH9 LNX2 Homo sapiens Q8N448
Y2H Array
29892012
Intra
IP6K2 Q9UHH9 LNX2 Homo sapiens Q8N448
Y2H Array
31515488
Intra
IP6K2 Q9UHH9 ZBTB2 Homo sapiens Q8N680
Y2H Prey Pooling
32296183
Intra
IP6K2 Q9UHH9 ZBTB2 Homo sapiens Q8N680
Y2H Array
32296183
Intra
IP6K2 Q9UHH9 TP53 Homo sapiens P04637
Pull Down
21078964
Intra
IP6K2 Q9UHH9 TP53 Homo sapiens P04637
Anti Bait CoIP
21078964
Intra
IP6K2 Q9UHH9 RBPMS Homo sapiens Q93062
Y2H Array
25416956
Intra
IP6K2 Q9UHH9 MEOX2 Homo sapiens P50222
Y2H Prey Pooling
25416956
Intra
IP6K2 Q9UHH9 MEOX2 Homo sapiens P50222
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-150607 UNC7467 Inhibitor 99.87% Unkown
HY-153530 LI-2242 Inhibitor 98.83% Unkown
HY-171099 SC-919 Inhibitor 98.68% Unkown
HY-122706A IP6K2-IN-2 Inhibitor 99.70% Unkown
HY-161032 IP6K2-IN-1 Inhibitor 99.47% Unkown
HY-175477 UNC9750 Inhibitor / Unkown
HY-RS06862 IP6K2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus IP6K2 VGNC VGNC:62952
Mus musculus IP6K2 MGD MGI:1923750
Macaca mulatta IP6K2 VGNC VGNC:73612
Rattus norvegicus IP6K2 RGD RGD:620529
Canis familiaris IP6K2 VGNC VGNC:42062
Bos taurus IP6K2 VGNC VGNC:30238
Others IP6K2 NCBI