NADSYN1 - NAD synthetase 1 Gene

Also Known as VCRL3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55191

About NADSYN1

Cytogenetic location: 11q13.4 Genomic coordinates (GRCh38): 11:71,453,203-71,501,816 (from NCBI)

This gene has 23 transcripts (splice variants), 212 orthologues and is associated with 3 phenotypes. Ubiquitous expression in bone marrow (RPKM 25.3), duodenum (RPKM 20.8) and 25 other tissues.

Summary

Nicotinamide adenine dinucleotide (NAD) is a coenzyme in metabolic redox reactions, a precursor for several cell signaling molecules, and a substrate for protein posttranslational modifications. NAD synthetase (EC 6.3.5.1) catalyzes the final step in the biosynthesis of NAD from nicotinic acid adenine dinucleotide (NaAD).[supplied by OMIM, Apr 2004]

NADSYN1 Products (1)

mRNA Protein Name
NM_018161.5 NP_060631.2 glutamine-dependent NAD(+) synthetase

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables NAD+ synthase (glutamine-hydrolyzing) activity IMP
IMP: Inferred from mutant phenotype
31883644 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Références Source
involved in 'de novo' NAD biosynthetic process IMP
IMP: Inferred from mutant phenotype
31883644 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NADSYN1 Protein Structure

CN_hydrolase

CN_hydrolase: Carbon-nitrogen hydrolase (6 - 200)

NAD_synthase

NAD_synthase: NAD synthase (339 - 602)

  • 0
  • 200
  • 400
  • 600
  • 706 a.a.
Protein Preferred Names Protein Names

glutamine-dependent NAD(+) synthetase

  • NAD(+) synthase

NADSYN1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
NADSYN1 Q6IA69 q9h614_human Homo sapiens Q9H614
Y2H Prey Pooling
25416956
Intra
NADSYN1 Q6IA69 NOXA1 Homo sapiens Q86UR1-2
Validated Y2H
32296183
Intra
NADSYN1 Q6IA69 TFG Homo sapiens Q92734
Validated Y2H
32296183
Intra
NADSYN1 Q6IA69 CUTC Homo sapiens Q9NTM9
Y2H Array
31515488
Intra
NADSYN1 Q6IA69 CUTC Homo sapiens Q9NTM9
Y2H Prey Pooling
32296183
Intra
NADSYN1 Q6IA69 CUTC Homo sapiens Q9NTM9
Validated Y2H
32296183
Intra
NADSYN1 Q6IA69 CUTC Homo sapiens Q9NTM9
Y2H Array
32296183
Intra
NADSYN1 Q6IA69 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
NADSYN1 Q6IA69 MYO15B Homo sapiens Q96JP2
Y2H Prey Pooling
32296183
Intra
NADSYN1 Q6IA69 MYO15B Homo sapiens Q96JP2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Vertebral, Cardiac, Renal, And Limb Defects Syndrome 3

  • VCRL3

  • Congenital Nad Deficiency Disorder 3

  • Congenital Nad Deficiency Disorder
Congenital Vertebral-Cardiac-Renal Anomalies Syndrome

  • Congenital Nad Deficiency Disorder
Superficial Keratitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS09006 NADSYN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NADSYN1 MGD MGI:1926164
Canis familiaris NADSYN1 VGNC VGNC:43606
Macaca mulatta NADSYN1 VGNC VGNC:75048
Bos taurus NADSYN1 VGNC VGNC:31865
Rattus norvegicus NADSYN1 RGD RGD:727801
Felis catus NADSYN1 VGNC VGNC:63711
Others NADSYN1 NCBI