NELFA - negative elongation factor complex member A Gene

Also Known as WHSC2; NELF-A; P/OKcl.15

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7469

About NELFA

Cytogenetic location: 4p16.3 Genomic coordinates (GRCh38): 4:1,982,723-2,008,974 (from NCBI)

Ubiquitous expression in testis (RPKM 9.8), ovary (RPKM 6.6) and 25 other tissues.

Summary

This gene is expressed ubiquitously with higher levels in fetal than in adult tissues. It encodes a protein sharing 93% sequence identity with the mouse protein. Wolf-Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt-Rogers-Danks syndrome. The encoded protein is found to be capable of reacting with HLA-A2-restricted and tumor-specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of Cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation. [provided by RefSeq, Jul 2008]

NELFA Products (1)

mRNA	Protein	Name
NM_005663.5	NP_005654.4	negative elongation factor A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	30135580	GOA
enables molecular adaptor activity	IPI IPI: Inferred from physical interaction	30135580	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12612062	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in negative regulation of transcription elongation by RNA polymerase II	IDA IDA: Inferred from direct assay	12612062	GOA

Cellular Component GO Annotation	Evidence	Références	Source
part of NELF complex	IDA IDA: Inferred from direct assay	12612062	GOA
part of NELF complex	IPI IPI: Inferred from physical interaction	12612062	GOA
located in nucleus	IDA IDA: Inferred from direct assay	12612062	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
negative elongation factor A	wolf-Hirschhorn syndrome candidate 2 protein

NELFA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	NELFA	Q9H3P2	OPRM1	Homo sapiens	P35372	Ub Reconstruction	28298427
Intra	NELFA	Q9H3P2	NELFCD	Homo sapiens	Q8IXH7	Y2H Array	20211142
Intra	NELFA	Q9H3P2	NELFCD	Homo sapiens	Q8IXH7	Anti Tag CoIP	33961781
Intra	NELFA	Q9H3P2	NELFCD	Homo sapiens	Q8IXH7-4	GMS	12612062
Intra	NELFA	Q9H3P2	NELFCD	Homo sapiens	Q8IXH7-4	Anti Tag CoIP	28514442
Intra	NELFA	Q9H3P2	NELFCD	Homo sapiens	Q8IXH7-4	Anti Tag CoIP	26496610
Intra	NELFA	Q9H3P2	NELFCD	Homo sapiens	Q8IXH7-4	Pull Down	12612062
Intra	NELFA	Q9H3P2	NELFCD	Homo sapiens	Q8IXH7-4	Anti Tag CoIP	12612062
Intra	NELFA	Q9H3P2	SIAH1	Homo sapiens	Q8IUQ4	Y2H Array	25416956
Intra	NELFA	Q9H3P2	SIAH1	Homo sapiens	Q8IUQ4	Y2H Prey Pooling	25416956
Intra	NELFA	Q9H3P2	SIAH1	Homo sapiens	Q8IUQ4	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

NELFA Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P84797	WHSC2 Antibody (YA4494)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat
HY-P84797A	WHSC2 Antibody (YA4494)(PBS only)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Rat

Related Diseases

Diseases	Alias
Wolf-Hirschhorn Syndrome	Pitt-Rogers-Danks Syndrome WHS Chromosome 4p16.3 Deletion Syndrome Wittwer Syndrome 4p- Syndrome Pitt Syndrome 4p Deletion Syndrome Distal Deletion 4p Distal Monosomy 4p Telomeric Deletion 4p Prds 4p Syndrome Chromosome 4p Syndrome Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation Wolf Syndrome Chromosome 4p Deletion Syndrome Chromosome 4p Monosomy Del Syndrome Monosomy 4p Partial Monosomy 4p Chromosome 4 Short Arm Deletion
Hepatitis D	Delta Hepatitis Hepatitis Delta Hdv Hepatitis D Virus Hepatitis D Infection
Waardenburg Syndrome, Type 3	Waardenburg Syndrome Type 3 Klein-Waardenburg Syndrome WS3 Waardenburg Syndrome With Upper Limb Anomalies Waardenburg Syndrome Type Iii Waardenburg Syndrome, Type Iii White Forelock Syndrome With Multiple Congenital Malformations Waardenburg Syndrome With Limb Anomalies Waardenburg Syndrome 3 White Forelock With Malformations Klein'S Syndrome
Oligomeganephronia	Oligomeganephronic Renal Hypoplasia Oligomeganephronic Hypoplasia Of Kidney
Chromosomal Deletion Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS09201	NELFA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21664	Nelfa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28182	Nelfa Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NELFA	VGNC	VGNC:75164
Felis catus	NELFA	VGNC	VGNC:63771
Canis familiaris	NELFA	VGNC	VGNC:43736
Bos taurus	NELFA	VGNC	VGNC:32000
Mus musculus	NELFA	MGD	MGI:1346098
Rattus norvegicus	NELFA	RGD	RGD:1305556
Others	NELFA	NCBI