LAPTM5 - lysosomal protein transmembrane 5 Gene

Also Known as CLAST6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7805

About LAPTM5

Cytogenetic location: 1p35.2 Genomic coordinates (GRCh38): 1:30,732,469-30,757,774 (from NCBI)

This gene has 3 transcripts (splice variants), 115 orthologues and 2 paralogues. Broad expression in bone marrow (RPKM 488.0), lymph node (RPKM 349.3) and 15 other tissues.

Summary

This gene encodes a transmembrane receptor that is associated with lysosomes. The encoded protein, also known as E3 protein, may play a role in hematopoiesis. [provided by RefSeq, Feb 2009]

LAPTM5 Products (1)

mRNA Protein Name
NM_006762.3 NP_006753.1 lysosomal-associated transmembrane protein 5

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
17116753 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
17116753 GOA
Biological Process GO Annotation Evidence Références Source
involved in activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
28464033 GOA
involved in defense response to tumor cell IDA
IDA: Inferred from direct assay
19787053 GOA
involved in induction of programmed cell death IDA
IDA: Inferred from direct assay
19787053 GOA
involved in negative regulation of autophagic cell death IDA
IDA: Inferred from direct assay
19787053 GOA
involved in positive regulation of lysosomal membrane permeability IDA
IDA: Inferred from direct assay
19787053 GOA
Cellular Component GO Annotation Evidence Références Source
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
22009753 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
17116753 GOA
located in lysosome IDA
IDA: Inferred from direct assay
8661146 GOA
located in perinuclear region of cytoplasm IMP
IMP: Inferred from mutant phenotype
28464033 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
8661146 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
17116753 GOA
located in transport vesicle IDA
IDA: Inferred from direct assay
19787053 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LAPTM5 Protein Structure

Mtp

Mtp: Golgi 4-transmembrane spanning transporter (28 - 261)

  • 0
  • 100
  • 200
  • 262 a.a.
Protein Preferred Names Protein Names

lysosomal-associated transmembrane protein 5

  • CD40-ligand-activated specific transcripts

LAPTM5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
LAPTM5 Q13571 LDLRAD1 Homo sapiens Q5T700
Y2H Prey Pooling
25416956
Intra
LAPTM5 Q13571 DISP1 Homo sapiens Q96F81
Y2H Prey Pooling
25416956
Intra
LAPTM5 Q13571 RTP2 Homo sapiens Q5QGT7
Validated Y2H
32296183
Intra
LAPTM5 Q13571 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra
LAPTM5 Q13571 AIG1 Homo sapiens Q9NVV5-2
Validated Y2H
32296183
Intra
LAPTM5 Q13571 C4orf3 Homo sapiens Q8WVX3-2
Validated Y2H
32296183
Intra
LAPTM5 Q13571 CLDN19 Homo sapiens Q8N6F1-2
Validated Y2H
32296183
Intra
LAPTM5 Q13571 KIR3DL3 Homo sapiens Q8N743
Validated Y2H
32296183
Intra
LAPTM5 Q13571 KIR3DL3 Homo sapiens Q8N743
Y2H Array
32296183
Intra
LAPTM5 Q13571 KIR3DL3 Homo sapiens Q8N743
Y2H Prey Pooling
32296183
Intra
LAPTM5 Q13571 MRPL18 Homo sapiens Q9H0U6
Validated Y2H
32296183
Intra
LAPTM5 Q13571 INSIG2 Homo sapiens Q9Y5U4
Validated Y2H
32296183
Intra
LAPTM5 Q13571 UBE2J1 Homo sapiens Q9Y385
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pigmented Villonodular Synovitis

  • Diffuse Giant Cell Tumor Of Tenosynovium

  • Villous Tenosynovitis

  • Diffuse Pigmented Villonodular Synovitis

  • Diffuse-Type Gct

  • Diffuse-Type Giant Cell Tumor

  • Localized Pigmented Villonodular Synovitis

  • Tgct

  • Tsgct

  • Tenosynovial Giant Cell Tumor

  • Tenosynovial Giant Cell Tumors

  • Synovitis Pigmented Villonodular

  • Synovitis, Pigmented Villonodular

  • Fibrous Histiocytoma Of Tendon Sheath

  • Testicular Germ Cell Tumor

  • Chronic Haemorrhagic Villous Synovitis

  • Pvns - [Pigmented Villonodular Synovitis]

  • Villonodular Synovitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS07523 LAPTM5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19785 Laptm5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26282 Laptm5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LAPTM5 RGD RGD:621838
Bos taurus LAPTM5 VGNC VGNC:30788
Canis familiaris LAPTM5 VGNC VGNC:42584
Macaca mulatta LAPTM5 VGNC VGNC:74162
Felis catus LAPTM5 VGNC VGNC:63190
Mus musculus LAPTM5 MGD MGI:108046
Others LAPTM5 NCBI