NLRX1 - NLR family member X1 Gene

Also Known as NOD5; NOD9; NOD26; DLNB26; CLR11.3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79671

About NLRX1

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:119,168,334-119,184,016 (from NCBI)

This gene has 14 transcripts (splice variants), 193 orthologues and 20 paralogues. Ubiquitous expression in esophagus (RPKM 15.5), skin (RPKM 7.2) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the NLR family and localizes to the outer mitochondrial membrane. The encoded protein is a regulator of mitochondrial antivirus responses. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2013]

NLRX1 Products (12)

mRNA	Protein	Name
XM_005271669.2	XP_005271726.1	NLR family member X1 isoform X1
XM_006718904.2	XP_006718967.1	NLR family member X1 isoform X2
XM_047427589.1	XP_047283545.1	NLR family member X1 isoform X3
NM_001282143.2	NP_001269072.1	NLR family member X1 isoform 1 precursor
XM_047427588.1	XP_047283544.1	NLR family member X1 isoform X2
NM_170722.2	NP_733840.1	NLR family member X1 isoform 2 precursor
NM_024618.4	NP_078894.2	NLR family member X1 isoform 1 precursor
XM_011542980.2	XP_011541282.1	NLR family member X1 isoform X1
NM_001282144.2	NP_001269073.1	NLR family member X1 isoform 1 precursor
XM_047427586.1	XP_047283542.1	NLR family member X1 isoform X2
XM_047427587.1	XP_047283543.1	NLR family member X1 isoform X2
NM_001282358.2	NP_001269287.1	NLR family member X1 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18200010	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NLRX1 Protein Structure

NACHT

LRR_6

0
200
400
600
800
975 a.a.

Protein Preferred Names	Protein Names
NLR family member X1	NOD-like receptor X1 caterpiller protein 11.3 nucleotide-binding oligomerization domain protein 26 nucleotide-binding oligomerization domain protein 5 nucleotide-binding oligomerization domain protein 9 nucleotide-binding oligomerization domain, leucine rich repeat containing X1

NLRX1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Cross	NLRX1	Q86UT6	Sarm1	Mus musculus	Q6PDS3	Anti Tag CoIP	21903422

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Histiocytic Sarcoma	Malignant Histiocytosis
Mooren'S Ulcer	Mooren Ulcer Moorens Ulcer
Mitochondrial Complex V Deficiency, Nuclear Type 3	Mitochondrial Complex Iii Deficiency Nuclear Type 5 MC5DN3 Mitochondrial Complex Iii Deficiency, Nuclear Type 5 Mitochondrial Complex V Deficiency Nuclear Type 3 MC3DN5 Mitochondrial Complex V Deficiency, Atp5e Type Mitochondrial Complex Iii Deficiency, Nuclear 5 Mitochondrial Complex V Deficiency, Nuclear Type 3 Mitochondrial Complex V Deficiency Atp5e Type Mitochondrial Complex V Deficiency Type 3 Mitochondrial Complex V Deficiency, Nuclear, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-141521	Amelenodor	Activator	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-CE00479	(6Z,9Z,12Z,15Z,18Z,21Z)-Tetracosahexaenoyl-CoA	Modulator	/	Unkown
HY-RS09365	NLRX1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09366	Nlrx1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS09367	Nlrx1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-148285	Succinyl CoA		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NLRX1	VGNC	VGNC:43853
Macaca mulatta	NLRX1	VGNC	VGNC:75283
Bos taurus	NLRX1	VGNC	VGNC:32122
Mus musculus	NLRX1	MGD	MGI:2429611
Felis catus	NLRX1	VGNC	VGNC:63834
Rattus norvegicus	NLRX1	RGD	RGD:1311293
Others	NLRX1	NCBI