MOB2 - MOB kinase activator 2 Gene

Also Known as HCCA2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81532

About MOB2

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:1,469,448-1,486,779 (from NCBI)

This gene has 6 transcripts (splice variants), 223 orthologues and 6 paralogues. Ubiquitous expression in skin (RPKM 12.1), endometrium (RPKM 11.8) and 25 other tissues.

Summary

Predicted to enable metal ion binding activity. Predicted to act upstream of or within actin Cytoskeleton organization; positive regulation of neuron projection development; and positive regulation of protein phosphorylation. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MOB2 Products (2)

mRNA Protein Name
NM_001172223.3 NP_001165694.1 MOB kinase activator 2 isoform 1
NM_053005.5 NP_443731.2 MOB kinase activator 2 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
24366813 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MOB2 Protein Structure

Mob1_phocein

Mob1_phocein: Mob1/phocein family (64 - 230)

  • 0
  • 100
  • 200
  • 268 a.a.
Protein Preferred Names Protein Names

MOB kinase activator 2

  • MOB2 Mps One Binder homolog

MOB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
MOB2 Q70IA6 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
MOB2 Q70IA6 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra
MOB2 Q70IA6 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
MOB2 Q70IA6 FAAP20 Homo sapiens Q6NZ36-4
Y2H Prey Pooling
32296183
Intra
MOB2 Q70IA6 FAAP20 Homo sapiens Q6NZ36-4
Y2H Array
32296183
Intra
MOB2 Q70IA6 OR5H1 Homo sapiens A6NKK0
Y2H Prey Pooling
32296183
Intra
MOB2 Q70IA6 OR5H1 Homo sapiens A6NKK0
Y2H Array
32296183
Intra
MOB2 Q70IA6 MIIP Homo sapiens Q5JXC2
Y2H Prey Pooling
32296183
Intra
MOB2 Q70IA6 MIIP Homo sapiens Q5JXC2
Y2H Array
32296183
Intra
MOB2 Q70IA6 SFT2D2 Homo sapiens O95562
Y2H Prey Pooling
32296183
Intra
MOB2 Q70IA6 SFT2D2 Homo sapiens O95562
Validated Y2H
32296183
Intra
MOB2 Q70IA6 SFT2D2 Homo sapiens O95562
Y2H Array
32296183
Intra
MOB2 Q70IA6 STK38 Homo sapiens Q15208
Anti Tag CoIP
33961781
Intra
MOB2 Q70IA6 FRA10AC1 Homo sapiens Q70Z53
Y2H Prey Pooling
32296183
Intra
MOB2 Q70IA6 FRA10AC1 Homo sapiens Q70Z53
Validated Y2H
32296183
Intra
MOB2 Q70IA6 FRA10AC1 Homo sapiens Q70Z53
Y2H Array
32296183
Intra
MOB2 Q70IA6 CCDC90B Homo sapiens Q9GZT6
Validated Y2H
32296183
Intra
MOB2 Q70IA6 CCDC90B Homo sapiens Q9GZT6
Y2H Array
32296183
Intra
MOB2 Q70IA6 CCDC90B Homo sapiens Q9GZT6
Y2H Prey Pooling
32296183
Intra
MOB2 Q70IA6 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
MOB2 Q70IA6 ATG3 Homo sapiens Q9NT62
Validated Y2H
32296183
Intra
MOB2 Q70IA6 ATG3 Homo sapiens Q9NT62
Y2H Array
32296183
Intra
MOB2 Q70IA6 ATG3 Homo sapiens Q9NT62
Y2H Prey Pooling
32296183
Intra
MOB2 Q70IA6 STK38L Homo sapiens Q9Y2H1
Anti Tag CoIP
33961781
Intra
MOB2 Q70IA6 STK38L Homo sapiens Q9Y2H1
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Van Maldergem Syndrome

  • Van Maldergem Wetzburger Verloes Syndrome

  • Cerebro-Facio-Articular Syndrome

  • Cerebro-Facio-Articular Syndrome Of Van Maldergem

  • Cerebrofacioarticular Syndrome

  • Cerebro Facio Articular Syndrome

  • Van Maldergem-Wetzburger-Verloes Syndrome
Periventricular Nodular Heterotopia

  • Periventricular Heterotopia

  • Pvnh

  • Familial Nodular Heterotopia

  • Heterotopia, Periventricular

  • Periventricular Heterotopia, X-Linked
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS08575 MOB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MOB2 VGNC VGNC:101353
Felis catus MOB2 VGNC VGNC:63545
Mus musculus MOB2 MGD MGI:1919891
Bos taurus MOB2 VGNC VGNC:31543
Canis familiaris MOB2 VGNC VGNC:43301
Rattus norvegicus MOB2 RGD RGD:1562983
Others MOB2 NCBI