Ppp1r9b - protein phosphatase 1, regulatory subunit 9B Gene

Also Known as Neb2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 84686

Summary

Enables several functions, including D2 Dopamine Receptor binding activity; enzyme binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; pallium development; and positive regulation of protein localization to cell periphery. Located in several cellular components, including dendritic spine; growth cone; and postsynaptic density. Biomarker of Parkinson's disease. Orthologous to human PPP1R9B (protein Phosphatase 1 regulatory subunit 9B). [provided by Alliance of Genome Resources, Apr 2022]

Ppp1r9b Products (2)

mRNA Protein Name
NM_053474.2 NP_445926.1 neurabin-2
NM_053474.2 NP_445926.1 neurabin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables D2 dopamine receptor binding IPI
IPI: Inferred from physical interaction
10391935 RGD
enables actin binding IDA
IDA: Inferred from direct assay
15135218 RGD
enables actin filament binding IDA
IDA: Inferred from direct assay
12417592 RGD
enables kinase binding IPI
IPI: Inferred from physical interaction
11182094 RGD
enables nucleic acid binding EXP
EXP: Inferred from Experiment
18028445 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9514910 RGD
enables protein kinase activity IDA
IDA: Inferred from direct assay
9653190 RGD
enables protein phosphatase 1 binding IDA
IDA: Inferred from direct assay
9275233 RGD
enables protein phosphatase 1 binding IPI
IPI: Inferred from physical interaction
12016225 RGD
enables protein phosphatase inhibitor activity IDA
IDA: Inferred from direct assay
12016225 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
12270929 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
16025302 RGD
Biological Process GO Annotation Evidence Références Source
involved in actin filament depolymerization IEP
IEP: Inferred from expression pattern
10620493 RGD
involved in cellular response to epidermal growth factor stimulus IEP
IEP: Inferred from expression pattern
10620493 RGD
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
16951259 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
16951259 RGD
involved in cellular response to peptide IEP
IEP: Inferred from expression pattern
21123436 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
16844384 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
9275233 RGD
involved in developmental process involved in reproduction IEP
IEP: Inferred from expression pattern
18096161 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
21123436 RGD
involved in learning IEP
IEP: Inferred from expression pattern
24069387 RGD
involved in male mating behavior IEP
IEP: Inferred from expression pattern
18726914 RGD
involved in positive regulation of protein localization IDA
IDA: Inferred from direct assay
18216290 RGD
involved in positive regulation of protein localization to actin cortical patch IMP
IMP: Inferred from mutant phenotype
18216290 RGD
involved in positive regulation of protein localization to plasma membrane IDA
IDA: Inferred from direct assay
9514910 RGD
involved in protein localization to actin cytoskeleton IMP
IMP: Inferred from mutant phenotype
18216290 RGD
involved in protein localization to cell periphery IMP
IMP: Inferred from mutant phenotype
18216290 RGD
involved in reproductive system development IEP
IEP: Inferred from expression pattern
18096161 RGD
involved in response to L-phenylalanine derivative IEP
IEP: Inferred from expression pattern
12112407 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
17443789 RGD
involved in response to amphetamine IEP
IEP: Inferred from expression pattern
19932152 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
17443789 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
22128856 RGD
involved in response to kainic acid IEP
IEP: Inferred from expression pattern
17443789 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
22959963 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
17408863 RGD
involved in response to prostaglandin E IEP
IEP: Inferred from expression pattern
23054057 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
20399784 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
22160164 RGD
Cellular Component GO Annotation Evidence Références Source
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
10514494 RGD
located in cytoplasmic side of dendritic spine plasma membrane IDA
IDA: Inferred from direct assay
9275233 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
15135218 RGD
located in dendritic spine head IDA
IDA: Inferred from direct assay
9275233 RGD
located in dendritic spine membrane IDA
IDA: Inferred from direct assay
9275233 RGD
located in dendritic spine neck IDA
IDA: Inferred from direct assay
9275233 RGD
is active in extrinsic component of postsynaptic membrane IDA
IDA: Inferred from direct assay
9275233 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
9275233 RGD
located in growth cone IDA
IDA: Inferred from direct assay
12270929 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
10620493 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
9275233 RGD
is active in spine apparatus IDA
IDA: Inferred from direct assay
9275233 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neurabin-2

  • PP1bp134

  • neurabin-II

  • neural tissue-specific F-actin-binding protein II

  • nuerabin 2

  • p130

  • spinophilin

Ppp1r9b Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Cross
Ppp1r9b O35274 PPP1CA Homo sapiens P62136
Anti Tag CoIP
25785436
Cross
Ppp1r9b O35274 PTPN6 Homo sapiens P29350
Anti Tag CoIP
25785436
Intra
Ppp1r9b O35274 Drd2 Rattus norvegicus P61169
Y2H
10391935
Intra
Ppp1r9b O35274 Ppp1cc Rattus norvegicus P63088
Pull Down
10391935
Intra
Ppp1r9b O35274 Ppp1cc Rattus norvegicus P63088
Imaging
18216290
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS11006 PPP1R9B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppp1r9b NCBI NCBI:84687