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ASMTL - acetylserotonin O-methyltransferase like Gene

Also Known as ASTML; ASMTLX; ASMTLY

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8623

About ASMTL

Cytogenetic location: Xp22.33 Genomic coordinates (GRCh38): X:1,403,139-1,453,756 (from NCBI)

This gene has 6 transcripts (splice variants), 168 orthologues and 1 paralogue. Ubiquitous expression in ovary (RPKM 11.8), prostate (RPKM 10.4) and 25 other tissues.

Summary

The protein encoded by this gene has an N-terminus that is similar to the multicopy associated filamentation (maf) protein of Bacillus subtilis and to orfE of Escherichia coli, while the C-terminus is similar to N-acetylserotonin O-methyltransferase. This gene is located in the pseudoautosomal region 1 (PAR1) of X and Y chromosomes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

ASMTL Products (3)

mRNA	Protein	Name
NM_001173473.2	NP_001166944.1	probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform 2
NM_001173474.2	NP_001166945.1	probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform 3
NM_004192.4	NP_004183.2	probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASMTL Protein Structure

Maf

Methyltransf_2

0
100
200
300
400
500
621 a.a.

Protein Preferred Names	Protein Names
probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein	N-acetylserotonin O-methyltransferase-like protein

ASMTL Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	ASMTL	O95671	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	ASMTL	O95671	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	ASMTL	O95671	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	ASMTL	O95671	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	ASMTL	O95671	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
Intra	ASMTL	O95671	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	ASMTL	O95671	DCTN1	Homo sapiens	Q14203-5	Y2H Array	32814053
Intra	ASMTL	O95671	DCTN1	Homo sapiens	Q14203-5	Y2H Pooling	32814053
Intra	ASMTL	O95671	DCTN1	Homo sapiens	Q14203-5	Validated Y2H	32814053
Intra	ASMTL	O95671	PNMA1	Homo sapiens	Q8ND90	Y2H Prey Pooling	25416956
Intra	ASMTL	O95671	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	ASMTL	O95671	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	ASMTL	O95671	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	ASMTL	O95671	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
Intra	ASMTL	O95671	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
Intra	ASMTL	O95671	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	ASMTL	O95671	TDO2	Homo sapiens	P48775	Y2H Prey Pooling	25416956
Intra	ASMTL	O95671	TDO2	Homo sapiens	P48775	Validated Y2H	32296183
Intra	ASMTL	O95671	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
Intra	ASMTL	O95671	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	ASMTL	O95671	KRT31	Homo sapiens	Q15323	Validated Y2H	32296183
Intra	ASMTL	O95671	KRT31	Homo sapiens	Q15323	Y2H Array	25416956
Intra	ASMTL	O95671	KRT31	Homo sapiens	Q15323	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-RS01097	ASMTL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ASMTL	RGD	RGD:1306877
Felis catus	ASMTL	VGNC	VGNC:68357
Bos taurus	ASMTL	VGNC	VGNC:26215
Others	ASMTL	NCBI