KLHL13 - kelch like family member 13 Gene

Also Known as BKLHD2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 90293

About KLHL13

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:117,897,813-118,131,050 (from NCBI)

This gene has 8 transcripts (splice variants), 215 orthologues and 54 paralogues. Broad expression in endometrium (RPKM 9.9), kidney (RPKM 3.7) and 15 other tissues.

Summary

This gene encodes a BTB and kelch domain containing protein and belongs to the kelch repeat domain containing superfamily of proteins. The encoded protein functions as an adaptor protein that complexes with Cullin 3 and Other proteins to form the Cullin 3-based E3 ubiquitin-protein Ligase complex. This complex is necessary for proper chromosome segregation and completion of cytokinesis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

KLHL13 Products (9)

mRNA Protein Name
NM_001168299.2 NP_001161771.1 kelch-like protein 13 isoform b
NM_001168300.2 NP_001161772.1 kelch-like protein 13 isoform c
NM_001168301.2 NP_001161773.1 kelch-like protein 13 isoform d
NM_001168302.2 NP_001161774.1 kelch-like protein 13 isoform d
NM_001168303.4 NP_001161775.2 kelch-like protein 13 isoform e
NM_001394863.1 NP_001381792.1 kelch-like protein 13 isoform a
NM_001394864.1 NP_001381793.1 kelch-like protein 13 isoform f
NM_001394866.1 NP_001381795.1 kelch-like protein 13 isoform g
NM_033495.4 NP_277030.2 kelch-like protein 13 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
14528312 GOA
contributes to ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
17543862 GOA
Biological Process GO Annotation Evidence Références Source
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
17543862 GOA
involved in regulation of cytokinesis IMP
IMP: Inferred from mutant phenotype
17543862 GOA
Cellular Component GO Annotation Evidence Références Source
part of Cul3-RING ubiquitin ligase complex IDA
IDA: Inferred from direct assay
14528312 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLHL13 Protein Structure

BTB

BTB: BTB/POZ domain (82 - 188)

BACK

BACK: BTB And C-terminal Kelch (196 - 297)

Kelch_1

Kelch_1: Kelch motif (378 - 428)

Kelch_1

Kelch_1: Kelch motif (436 - 475)

Kelch_1

Kelch_1: Kelch motif (479 - 521)

Kelch_1

Kelch_1: Kelch motif (527 - 573)

Kelch_1

Kelch_1: Kelch motif (578 - 619)

  • 0
  • 200
  • 400
  • 600
  • 655 a.a.
Protein Preferred Names Protein Names

kelch-like protein 13

  • BTB and kelch domain containing 2

KLHL13 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
KLHL13 Q9P2N7 CUL3 Homo sapiens Q13618
Anti Bait CoIP
17543862
Intra
KLHL13 Q9P2N7 CUL3 Homo sapiens Q13618
Anti Tag CoIP
21145461
Intra
KLHL13 Q9P2N7 CUL3 Homo sapiens Q13618
TAP
21145461
Intra
KLHL13 Q9P2N7 CUL3 Homo sapiens Q13618
Anti Tag CoIP
30190310
Intra
KLHL13 Q9P2N7 AURKB Homo sapiens Q96GD4
Anti Bait CoIP
17543862
Cross: Cross-species interaction Intra: Intraspecies interaction

KLHL13 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P84848 KLHL13 Antibody (YA4545) WB, IHC-P, ICC/IF, FC, ELISA Human
HY-P84848A KLHL13 Antibody (YA4545)(PBS only) WB, IHC-P, ICC/IF, FC, ELISA Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS07357 KLHL13 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus KLHL13 VGNC VGNC:63143
Mus musculus KLHL13 MGD MGI:1914705
Bos taurus KLHL13 VGNC VGNC:30643
Canis familiaris KLHL13 VGNC VGNC:42449
Rattus norvegicus KLHL13 RGD RGD:1559646
Macaca mulatta KLHL13 VGNC VGNC:74105
Others KLHL13 NCBI