Glenthmycin E
Glenthmycin E is an antibacterial agent found in Australian sheep pasture-derived Streptomyces sp. CMB-PB041. Glenthmycin E inhibits growth of multiple bacterial and exhibits no detectable cytotoxicity to eukaryotic cells including fungal and human carcinoma cells. Glenthmycin E can be used for the research of bacterial infections.
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- CAS No.: 3040055-84-0
- Formule: C50H64O14
- Masse moléculaire:889.03
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
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| NCI-H460 | IC50 |
30 μM
Compound: 5
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Cytotoxicity against human NCI-H460 cells and measured after 48 hrs by MTT assay
Cytotoxicity against human NCI-H460 cells and measured after 48 hrs by MTT assay
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[PMID: 35640100] |
Glenthmycin E (0.01-30 μM; 16-24 h) inhibits the growth of Staphylococcus aureus ATCC 25923 (IC50 = 4.9 μM), Enterococcus faecalis (IC50 = 6.2 μM), methicillin-resistant S. aureus ATCC 43300 (IC50 = 3.9 μM), methicillin-resistant S. aureus ATCC 33591 (IC50 = 2.3 μM), and vancomycin-resistant Enterococci (IC50 = 3.2 μM)[1].
Glenthmycin E (48 h) does not exhibit significant cytotoxicity against SW620 or NCI-H460 human carcinoma cells (IC50 >30 μM), nor does it inhibit growth of Candida albicans, Escherichia coli, Mycobacterium bovis BCG, or Mycobacterium tuberculosis H37Ra at concentrations up to 30 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:human colorectal carcinoma (SW620), human lung carcinoma (NCI-H460) cells
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Concentration:10 nM-30 μM
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Incubation Time:48 h
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Result:Exhibited no significant cytotoxicity against SW620 or NCI-H460 cells (IC50 >30 μM).
Chemical Information
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CAS No. 3040055-84-0
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Masse moléculaire 889.03
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Formule C50H64O14
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SMILES
C[C@@]12[C@@]3(C[C@H](C(C(O)=O)=C2)C)C(O)=C(C([C@]4([C@@]5([H])[C@@](C=C([C@@]4([H])/C(C)=C/CC/C(C)=C/1)C)([H])[C@H](CC[C@@H]5C)O[C@H]6[C@@H]([C@@H]([C@@H]([C@H](O6)C)OC(C7=C(C=C(C=C7C)OC)OC)=O)O)O)C)=O)C(O3)=O
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Structure Classification
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Initial Source
Streptomyces sp.
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glenthmycin E Related Classifications
HY-N19290 Related Classifications
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- Glenthmycin E
- 3040055-84-0
- Bacterial
- Candida albicans
- methicillin-resistant S. aureus ATCC 43300
- SW620
- methicillin-resistant S. aureus ATCC 33591
- Staphylococcus aureus ATCC 25923
- NCI-H460
- methicillin-resistant Staphylococcus aureus
- Enterococcus faecalis
- Streptomyces sp. CMB-PB041
- vancomycin-resistant Enterococci
- Inhibitor
- inhibitor
- inhibit