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Cat. No.: HY-161877

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GS-7682

GS-7682 is an antiviral compound. GS-7682 has inhibitory activity against pneumoviruses and picornaviruses. GS-7682 can be used in the study of respiratory diseases such as asthma and chronic obstructive pulmonary disease.

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CAS No.: 2694736-39-3
Formule: C₃₀H₃₇N₆O₁₀P
Masse moléculaire:672.62

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

GS-7682 Chemical Structure

CAS No.: 2694736-39-3

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	CC₅₀	21.1 μM Compound: 1; GS-7682	Cytotoxicity against human A549 cells expressing hACE2 incubated for 28 hrs by Cell Titer Glo assay Cytotoxicity against human A549 cells expressing hACE2 incubated for 28 hrs by Cell Titer Glo assay	[PMID: 39018526]
Epithelial cell	CC₅₀	8.3 μM Compound: 1; GS-7682	Cytotoxicity against Normal human bronchial epithelial cells Cytotoxicity against Normal human bronchial epithelial cells	[PMID: 39018526]
H1-HeLa	CC₅₀	22.2 μM Compound: 1; GS-7682	Cytotoxicity against human H1-HeLa cells incubated for 96 hrs by Cell Titer Glo assay Cytotoxicity against human H1-HeLa cells incubated for 96 hrs by Cell Titer Glo assay	[PMID: 39018526]
HEp-2	CC₅₀	22.7 μM Compound: 1; GS-7682	Cytotoxicity against human Hep-2 cells incubated for 4 to 5 days by Cell Titer Glo assay Cytotoxicity against human Hep-2 cells incubated for 4 to 5 days by Cell Titer Glo assay	[PMID: 39018526]
LLC-MK2	CC₅₀	>2 μM Compound: 1; GS-7682	Cytotoxicity against rhesus monkey LLC-MK2 cells incubated for 5 days by MTS assay Cytotoxicity against rhesus monkey LLC-MK2 cells incubated for 5 days by MTS assay	[PMID: 39018526]
MDCK	CC₅₀	>2 μM Compound: 1; GS-7682	Cytotoxicity against MDCK cells by MTS assay Cytotoxicity against MDCK cells by MTS assay	[PMID: 39018526]
MT4	CC₅₀	3.24 μM Compound: 1; GS-7682	Cytotoxicity against human MT4 cells incubated for 5 days by Cell Titer Glo assay Cytotoxicity against human MT4 cells incubated for 5 days by Cell Titer Glo assay	[PMID: 39018526]
RD	CC₅₀	>2 μM Compound: 1; GS-7682	Cytotoxicity against human RD cells by MTS assay Cytotoxicity against human RD cells by MTS assay	[PMID: 39018526]

Chemical Information

CAS No. 2694736-39-3
Masse moléculaire 672.62
Formule C₃₀H₃₇N₆O₁₀P
SMILES

O=[P@](N[C@@H](C)C(OC)=O)(OC1=CC=CC=C1)OC[C@]2(C#N)[C@@H](OC(C(C)C)=O)[C@@H](OC(C(C)C)=O)[C@H](C3=CC=C4N3N=CN=C4N)O2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Siegel DS, et al. Discovery of GS-7682, a Novel 4'-Cyano-Modified C-Nucleoside Prodrug with Broad Activity against Pneumo- and Picornaviruses and Efficacy in RSV-Infected African Green Monkeys. J Med Chem. 2024 Jul 17. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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