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Cat. No.: HY-P1215A

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HS024 TFA

Name: HS024 TFA
Brand: MedChemExpress
SKU: HY-P1215A
Price: 140.00 USD
Availability: InStock
Rating: 5 (1 reviews)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

HS024 TFA is a peptide antagonist of melanocortin receptors with high affinity for the human melanocortin-4 receptor (MC4R). HS024 TFA blocks α-MSH (HY-P0252)-induced cAMP accumulation and MC4 receptor signaling. HS024 TFA induces dose-dependent feeding stimulation without affecting anxiety-related behavior or locomotor activity. HS024 TFA can be used in research related to MC4 receptor-mediated diseases, such as eating disorders.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté : 99.80%
Formule: C₅₈H₇₉N₁₉O₁₀S₂·xC₂HF₃O₂
Masse moléculaire:1266.50 (free base)

Stockage:

Sealed storage, away from moisture.

Powder -80°C, 2 years , -20°C, 1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

HS024 TFA Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

IC₅₀ & Target

^[1]

MC4R

0.29 nM (Ki)

Voir tous les produits spécifiques à Isoform Melanocortin Receptor :

In Vitro

HS024 TFA is a selective MC4 receptor antagonist with a K_i of 0.29 nM in COS-1 cells expressing the human MC4 receptor^[1].
HS024 TFA blocks intracellular cAMP accumulation triggered by α-MSH (HY-P0252) in COS-1 cells expressing human MC1, MC3, MC4, and MC5 receptors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

HS024 (0.1-1.0 nmol; i.c.v.; single injection on each test day; repeated every three days) TFA induces a dose-dependent increase in food intake in free-feeding Wistar rats^[1].
HS024 (0.02-0.1 nmol; i.c.v.; single injection 20 min before testing) TFA does not alter exploratory/locomotor activity in the elevated plus maze or open field^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Protocol for Open Field Test (OF)

Chemical Information

Appearance Solid
Masse moléculaire 1266.50 (free base)
Formule C₅₈H₇₉N₁₉O₁₀S₂·xC₂HF₃O₂
Color White to off-white
Sequence

Ac-Cys-{Nle}-Arg-His-{D-2Nal}-Arg-Trp-Gly-Cys-NH2 (Disulfide bridge:Cys1-Cys9)
Sequence Shortening

Ac-C-{Nle}-RH-{D-2Nal}-RWGC-NH2 (Disulfide bridge:Cys1-Cys9)
Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Journal Impact Factor

J Neuroinflammation

A microglial LCN2-MC4R signaling axis drives silica-induced neuronal damage via C1q release. [Abstract]

2026 Jan 23;23(1):70. PMID: 41578331

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 50 mg/mL (Need ultrasonic)

View the Complete Stock Solution Preparation Table

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (295 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Kask A, et al. Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology. 1998 Dec;139(12):5006-14. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

HS024 TFA

1 Cited Publications

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Solvant et solubilité
- In Vitro
Pureté et documentation
Références

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HS024 TFA

Publications Citing Use of MedChemExpress (MCE) HS024 TFA

Voir tous les produits spécifiques à Isoform Melanocortin Receptor