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Cat. No.: HY-A0160

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Indalpine

Name: Indalpine
Brand: MedChemExpress
SKU: HY-A0160
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(Synonyms: LM 5008)

Indalpine (LM 5008) is a potent and selective 5-HT uptake blocker. Indalpine is potent in displacing ³H-5-HT bound to brain membranes with the IC₅₀ of 36 μM. Indalpine, two antidepressant agent.

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CAS No.: 63758-79-2
Formule: C₁₅H₂₀N₂
Masse moléculaire:228.33

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Indalpine Chemical Structure

CAS No.: 63758-79-2

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Description

Indalpine (LM 5008) is a potent and selective 5-HT uptake blocker. Indalpine is potent in displacing ³H-5-HT bound to brain membranes with the IC₅₀ of 36 μM^[1]. Indalpine, two antidepressant agent^[2].

In Vivo

In keeping with its potent reuptake-blocking property, acute IV Indalpine produces a marked decrease in the firing rate of dorsal raphe 5-HT neurons (ED50 0.33 mg/kg). The firing rate of dorsal raphe 5-HT neurons is assessed following 2-, 7- and 14-day treatments with Indalpine (5 mg/day IP). After 2 days, the firing rate of 5-HT neurons is greatly reduced, after 7 days it has recovered partially and after 14 days it has returned to normal^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 63758-79-2
Masse moléculaire 228.33
Formule C₁₅H₂₀N₂
SMILES

C1(CCC2CCNCC2)=CNC3=C1C=CC=C3
Synonyms

LM 5008
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. R Samanin, et al. Further studies on the mechanism of serotonin-dependent anorexia in rats. Psychopharmacology (Berl). 1980;68(1):99-104. [Content Brief]

[2]. P Blier, et al. Effects of the two antidepressant drugs mianserin and Indalpine on the serotonergic system: single-cell studies in the rat. Psychopharmacology (Berl). 1984;84(2):242-9. [Content Brief]

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Indalpine

Duloxetine hydrochloride

Venlafaxine hydrochloride

Fluvoxamine maleate

Dapoxetine hydrochloride

ZZL-7

Venlafaxine hydrochloride (Standard)

Adoxosidic acid

Citalopram-d4 hydrobromide

(S)-Venlafaxine

Ampreloxetine hydrochloride

Duloxetine-d7

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Indalpine

Duloxetine hydrochloride

Venlafaxine hydrochloride

Fluvoxamine maleate

Dapoxetine hydrochloride

ZZL-7

Venlafaxine hydrochloride (Standard)

Adoxosidic acid

Citalopram-d4 hydrobromide

(S)-Venlafaxine

Ampreloxetine hydrochloride

Duloxetine-d7

Duloxetine hydrochloride (Standard)

Activité biologique

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Pureté et documentation

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Indalpine Related Classifications

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