LabMol-301
LabMol-301 inhibits both NS5 RdRp and NS2B-NS3pro activity (IC50: 0.8 and 7.4 μM, respectively). LabMol-301 has a cytoprotective effect and prevents Zika virus (ZIKV)-induced cell death.
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- CAS No.: 1360243-08-8
- Formule: C18H16N6
- Masse moléculaire:316.36
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
NS5 RdRp, NS2B-NS3pro[1]
LabMol-301 (20 μM) shows 99% inhibition rate of NS5 RdRp activity[1].
LabMol-301 (10 μM) inhibits more than 80% of the NS2B-NS3pro protease activity[1].
LabMol-301 interacts with ZIKV NS2B-NS3pro at the allosteric site relied on a highly hydrophobic complementarity between the molecule’s surfaces and the protein[1].
LabMol-301 is able to protect GSC387 cell from cell death induced by ZIKV (EC50: 6.68 μM)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1360243-08-8
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Masse moléculaire 316.36
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Formule C18H16N6
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SMILES
NC1=C(C2=C3C(NC=C3)=NC(NCC4=CC=CN=C4)=C2)C=NC=C1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
LabMol-301 Related Classifications
HY-151526 Related Classifications
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