LCC-12 formate
Based on 1 Customer Validation
LCC-12 formate is a mitochondria-targeted Copper2+ -selective binder and metabolic/epigenetic reprogramming agent. LCC-12 formate inhibits NAD (H) redox cycling and reduces the NAD (H) pool. LCC-12 formate downregulates the expression of inflammatory genes and improves outcomes in mouse models of bacterial sepsis, endotoxemia, and SARS-CoV-2 infection. LCC-12 formate can be used in research related to acute inflammation, endotoxemia, sepsis, and SARS-CoV-2 infection.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.90%
- Formule: C17H38N10O2
- Masse moléculaire:414.55
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
LCC-12 (10 μM) formate reduces the levels of mitochondrial NAD+ and NADH pools in primary activated monocyte-derived macrophages (aMDM)[1].
LCC-12 formate selectively forms a stable monometallic complex with copper (II) in a cell-free system, while it shows no significant binding to most other divalent metal ions or copper (I)[2].
LCC-12 formate inhibits copper (II)-catalyzed redox cycling of NADH to NAD+ in a dose-dependent manner in a cell-free system mimicking the mitochondrial matrix[2].
LCC-12 formate induces epigenetic reprogramming in activated monocyte-derived macrophages, increases histone methylation levels, decreases histone acetylation levels, and downregulates pro-inflammatory gene expression and cytokine secretion[2].
LCC-12 formate inhibits the activation of immune cells with upregulated CD44, and exerts effects on CD44-related copper-dependent cellular plasticity[2].
LCC-12 formate potently interferes with the activation of monocyte-derived macrophages and inhibits CD44-associated epithelial-mesenchymal transition in cancer cells[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
LCC-12 (i.p.) formate protects mice against LPS-induced death and prevents hypothermia[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Appearance Solid
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Masse moléculaire 414.55
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Formule C17H38N10O2
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Color White to off-white
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SMILES
NC(NC(NCCCCCCCCCCCCNC(NC(N)=N)=N)=N)=N.O=CO
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Pureté et documentation
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Fiche technique (267 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Solier S, et al. A druggable copper-signalling pathway that drives inflammation. Nature. 2023 May;617(7960):386-394. [Content Brief]
[3]. Weiskirchen R. Targeting copper to combat macrophage-driven inflammation: a potential advanced therapeutic strategy. Signal Transduct Target Ther. 2023 Sep 11;8(1):339. [Content Brief]
[4]. Flemming A, et al. Copper boosts pro-inflammatory state of macrophages. Nature reviews. Immunology. 2023 Jun;23(6):344. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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