country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-113456

Copy Link Print Information

Leukotriene D4

Name: Leukotriene D4
Brand: MedChemExpress
SKU: HY-113456
Price: 180.00 USD
Availability: InStock
Rating: 5 (3 reviews)

3 Cited Publications

Avis client

Based on 3 publication(s) in Google Scholar

Leukotriene D4 is a potent bronchoconstrictor. Leukotriene D4 has the potential for the research of asthma. Leukotriene D4 induces edema and increases capillary permeability.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté : 98.5%
CAS No.: 73836-78-9
Formule: C₂₅H₄₀N₂O₆S
Masse moléculaire:496.66

Stockage:

Solution, -20°C, 2 years

Leukotriene D4 Chemical Structure

CAS No.: 73836-78-9

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vivo
- Essai clinique
Chemical Information
Publications (3)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Leukotriene D4 is a potent bronchoconstrictor. Leukotriene D4 has the potential for the research of asthma. Leukotriene D4 induces edema and increases capillary permeability^[1]^[2].

IC₅₀ & Target

Human Endogenous Metabolite

Voir tous les produits spécifiques à Isoform Endogenous Metabolite :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO-K1	IC₅₀	0.7 nM Compound: LTD4	Displacement of [3H]LTD4 from human recombinant cysteinyl leukotriene receptor 1 expressed in CHOK1 cells after 30 mins Displacement of [3H]LTD4 from human recombinant cysteinyl leukotriene receptor 1 expressed in CHOK1 cells after 30 mins	[PMID: 23403082]
Sf9	IC₅₀	5.48 μM Compound: Leukotrien D4	TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cells TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.055 uM) in membrane vesicles from Mrp2-expressing Sf9 cells	[PMID: 11306690]

In Vivo

Leukotriene D4 (1.5, 3, 6, 12, 24 μg/paw; injected intradermally) causes edema and increases capillary permeability in a dose-related manner in mouse^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

21-24 g, Balb/c male mice^[2]
Dosage:

1.5, 3, 6, 12, 24 µg/paw
Administration:

Injected intradermally (10 µL was injected into the left hind paw)
Result:

Caused significant edematous response and dye extravasation at doses of 1.5-6 ~g/paw.

Related Protocols :

Transepithelial/transendothelial electrical resistance assay

Essai clinique

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 73836-78-9
Appearance Liquid
Masse moléculaire 496.66
Formule C₂₅H₄₀N₂O₆S
Color Colorless to light yellow
SMILES

O=C(O)CNC([C@H](CS[C@@H]([C@@H](O)CCCC(O)=O)/C=C/C=C/C=C\C/C=C\CCCCC)N)=O
Structure Classification
- Others
Initial Source
- Endogenous metabolite
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Solution, -20°C, 2 years

Publications (3)

All Cell Migration/Invasion AssayELISABio/Physico-chemical Assay

Sort by:

Journal Impact Factor

Anal Chem

Ultrahigh Flow Regulated Discharge Coupling with Targeted Mass Spectrometry Analysis: Real Time Capturing Biomolecules in Exhaled Breath. [Abstract]

2025 May 13;97(18):9827-9835. PMID: 40302637
Cancer Cell Int

DPEP2 suppresses metastasis via NF-κB-mediated epithelial-mesenchymal transition and M2 polarization in p53-loss non-small cell lung cancer. [Abstract]

2025 Nov 17;25(1):408. PMID: 41250029

Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]

The transwell and wound healing analyses of Vector/DPEP2 cells cultured with M2 CM or LTD4 (Leukotriene D4, 100 nM, 48 h).

Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]

ELISA detected the level of LTD4 in the medium of M2 cocultured with Vector/DPEP2 cells.

Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]

Total LTD4 levels in lung metastases.
Res Sq

2026 Mar 11.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
SDS (796 KB)
- English - EN (796 KB)
- Français - FR (796 KB)
- Deutsch - DE (796 KB)
- Norwegian - NO (796 KB)
- Español - ES (796 KB)
- Swedish - SV (796 KB)
- Italian - IT (796 KB)
- Korean - KR (796 KB)
- Portuguese - PT (796 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Smith LJ, et al. The effect of inhaled leukotriene D4 in humans. Am Rev Respir Dis. 1985 Mar;131(3):368-72. [Content Brief]

[2]. Griswold DE, et al. Phlogistic activity of leukotriene D4 in the mouse. Inflammation. 1986 Mar;10(1):1-7. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

Leukotriene D4

3 Cited Publications

100 mg Obtenir un devis

Subscribe to the

MedChemExpress

Newsletter

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
- IC₅₀ & Target
- In Vivo
- Essai clinique
Chemical Information
Publications (3)
Pureté et documentation
Références

1/16
1/16

Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]

Customer Validation
The transwell and wound healing analyses of Vector/DPEP2 cells cultured with M2 CM or LTD4 (Leukotriene D4, 100 nM, 48 h).
1/16

Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]

Customer Validation
ELISA detected the level of LTD4 in the medium of M2 cocultured with Vector/DPEP2 cells.
1/16

Leukotriene D4 purchased from MedChemExpress. Usage Cited in: Cancer Cell Int. 2025 Nov 17;25(1):408. [Abstract]

Customer Validation
Total LTD4 levels in lung metastases.

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

Leukotriene D4

Publications Citing Use of MedChemExpress (MCE) Leukotriene D4

Voir tous les produits spécifiques à Isoform Endogenous Metabolite