LI-3948
Based on 1 Customer Validation
LI-3948 is a blood-brain barrier-penetrant IP6K1 inhibitor with an IC50 of 16 nM. LI-3948 reduces locomotor activity and grooming behavior in mice and induces hypothermia. LI-3948 is a moderate P-glycoprotein efflux substrate, with low clearance in rodents and high plasma protein binding. LI-3948 can be used for central nervous system-related research.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté : 99.85%
- CAS No.: 3024591-38-3
- Formule: C19H16Cl2FN3O3
- Masse moléculaire:424.25
-
Stockage:
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Protocole
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
IP6K1 16 nM (IC50) |
In Vitro
LI-3948 (Compound 29c) (30 min) is a potent IP6K1 inhibitor with an IC50 of 16 nM in the ADP-Glo enzymatic assay[1].
LI-3948 (5 μM; 120 min) is a moderate P-gp substrate in MDR1-MDCK cells, with an efflux ratio of 3.8 and an apical-to-basolateral Papp of 16 × 10−6 cm/s[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Parmacokinetics
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6J (male, 8 weeks old)[1]
-
Dosage:30 mg/kg
-
Administration:p.o.; single dose
-
Result:Locomotion was decreased relative to vehicle (t(12) = 2.562) and grooming was decreased (t(12.76) = 2.842).
Body temperature was uniformly and significantly decreased by roughly 3.5 °C measured 24 h after dosing.
Four mice, with similar exposure levels to the other six mice, exhibited locomotor activity similar to vehicle-treated mice.
No statistically significant decrease in IP7 levels in the brain was observed.
Chemical Information
-
CAS No. 3024591-38-3
-
Appearance Solid
-
Masse moléculaire 424.25
-
Formule C19H16Cl2FN3O3
-
Color White to off-white
-
SMILES
FC1=C(C(N)=O)C=CC(N2)=C1[C@]3(CC[C@H](OC4=NC=C(Cl)C=C4Cl)CC3)C2=O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
-20°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (235.71 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
-
Fiche technique (295 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.3571 mL | 11.7855 mL | 23.5710 mL | 58.9275 mL |
| 5 mM | 0.4714 mL | 2.3571 mL | 4.7142 mL | 11.7855 mL | |
| 10 mM | 0.2357 mL | 1.1786 mL | 2.3571 mL | 5.8928 mL | |
| 15 mM | 0.1571 mL | 0.7857 mL | 1.5714 mL | 3.9285 mL | |
| 20 mM | 0.1179 mL | 0.5893 mL | 1.1786 mL | 2.9464 mL | |
| 25 mM | 0.0943 mL | 0.4714 mL | 0.9428 mL | 2.3571 mL | |
| 30 mM | 0.0786 mL | 0.3929 mL | 0.7857 mL | 1.9643 mL | |
| 40 mM | 0.0589 mL | 0.2946 mL | 0.5893 mL | 1.4732 mL | |
| 50 mM | 0.0471 mL | 0.2357 mL | 0.4714 mL | 1.1786 mL | |
| 60 mM | 0.0393 mL | 0.1964 mL | 0.3929 mL | 0.9821 mL | |
| 80 mM | 0.0295 mL | 0.1473 mL | 0.2946 mL | 0.7366 mL | |
| 100 mM | 0.0236 mL | 0.1179 mL | 0.2357 mL | 0.5893 mL |
LI-3948 Related Classifications
HY-162821 Related Classifications
Powered by Bioz