country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-161417

Copy Link Print Information

LIMK-IN-2

LIMK-IN-2 (Compound 52) is an LIMK inhibitor. LIMK-IN-2 can suppress the cell migration of osteosarcoma and cervical cancer cells, demonstrating potential anti-angiogenic activity.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2747216-27-7
Formule: C₂₈H₂₇N₅O₂
Masse moléculaire:465.55

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

LIMK-IN-2 Chemical Structure

CAS No.: 2747216-27-7

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

LIMK-IN-2 (Compound 52) is an LIMK inhibitor. LIMK-IN-2 can suppress the cell migration of osteosarcoma and cervical cancer cells, demonstrating potential anti-angiogenic activity^[1].

Voir tous les produits spécifiques à Isoform LIM Kinase (LIMK) :

LIMK1
LIMK2

Cellular Effect

Cell Line	Type	Value	Description	References
Fibroblast	EC₅₀	>25 μM Compound: 52	Cytotoxicity against human skin fibroblast cells assessed as inhibition of cell growth measured after 48 hrs by Hoechst 33342 staining based analysis Cytotoxicity against human skin fibroblast cells assessed as inhibition of cell growth measured after 48 hrs by Hoechst 33342 staining based analysis	[PMID: 38669909]
HeLa	EC₅₀	26 μM Compound: 52	Cytotoxicity against human HeLa cells assessed as induction of cell death measured after 48 hrs by celltiter glo luminescent cell viability assay Cytotoxicity against human HeLa cells assessed as induction of cell death measured after 48 hrs by celltiter glo luminescent cell viability assay	[PMID: 38669909]
KHOS/NP	IC₅₀	6.2 μM Compound: 52	Cytotoxicity against human KHOS/NP cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based analysis Cytotoxicity against human KHOS/NP cells assessed as inhibition of cell growth incubated for 48 hrs by crystal violet staining based analysis	[PMID: 38669909]
U2OS	IC₅₀	9.5 μM Compound: 52	Cytotoxicity against human U2OS cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter Aqueous One Solution Cell Proliferation Assay Cytotoxicity against human U2OS cells assessed as inhibition of cell growth incubated for 48 hrs by CellTiter Aqueous One Solution Cell Proliferation Assay	[PMID: 38669909]

Chemical Information

CAS No. 2747216-27-7
Masse moléculaire 465.55
Formule C₂₈H₂₇N₅O₂
SMILES

COC1=CC=CC(C2=CC(NC(N3CCC(C4=C5C(NC=C5C6CC6)=NC=N4)=CC3)=O)=CC=C2)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Champiré A, et al. Tetrahydropyridine LIMK inhibitors: Structure activity studies and biological characterization. Eur J Med Chem. Published online April 9, 2024. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis

Amount: USD 0.00

Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

LIMK-IN-2

Voir tous les produits spécifiques à Isoform LIM Kinase (LIMK)

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

LIMK-IN-2 Related Classifications

HY-161417 Related Classifications