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Cat. No.: HY-165191

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LY214352

LY214352 is an antifungal agent that targets dihydroorotate dehydrogenase (DHO-DH). LY214352 exhibits antifungal activity against Aspergillus nidulans and agriculturally important ascomycete fungi. LY214352 can be used in studies related to grape gray mold, apple scab, and fungal infections caused by ascomycetes.

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CAS No.: 124495-31-4
Formule: C₁₅H₈Cl₂FNO
Masse moléculaire:308.13

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

LY214352 Chemical Structure

CAS No.: 124495-31-4

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

LY214352 (0.001-1000 μg/mL) potently inhibits dihydroorotate dehydrogenase from the sensitive strain A610 of Aspergillus nidulans, with an IC₅₀ of 0.04 μg/mL; in contrast, the IC₅₀ of this enzyme derived from the highly drug-resistant mutant strain 52-4 is > 100 μg/mL^[1].
LY214352 (72-96 h) inhibits the growth of the susceptible strain A610 of Aspergillus nidulans, with an IC₅₀ of 0.13 μg/mL; in contrast, the IC₅₀ of moderately resistant mutants is approximately 2.5 μg/mL, and that of highly resistant mutants is > 30 μg/mL^[1].
LY214352 potently and selectively inhibits the growth of Aspergillus nidulans by targeting its DHODH enzyme. It exhibits an MIC of <2 μg/mL against A. nidulans and an IC₅₀ of 0.04 μg/mL against A. nidulans DHODH, while showing no activity against non-target bacteria and fungi^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 124495-31-4
Masse moléculaire 308.13
Formule C₁₅H₈Cl₂FNO
SMILES

FC1=CC=C(OC=2C=CN=C3C(Cl)=CC=CC23)C(Cl)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Gustafson G, et al. Identification of a new antifungal target site through a dual biochemical and molecular-genetics approach. Curr Genet. 1996;30(2):159-165. [Content Brief]

[2]. Then RL, et al. Anti-infective strategies of the future: is there room for species-specific antibacterial agents? Curr Pharm Des. 2010;16(5):555-66.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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